F
Florian Meier
Researcher at Max Planck Society
Publications - 66
Citations - 3444
Florian Meier is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mass spectrometry & Chemistry. The author has an hindex of 20, co-authored 47 publications receiving 1893 citations. Previous affiliations of Florian Meier include North Carolina State University & University of Copenhagen.
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Journal ArticleDOI
Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer *
Florian Meier,Andreas-David Brunner,Scarlet Koch,Heiner Koch,Markus Lubeck,Michael Krause,Niels Goedecke,Jens Decker,Thomas Kosinski,Melvin A. Park,Nicolai Bache,Ole Hoerning,Jürgen Cox,Oliver Raether,Matthias Mann,Matthias Mann +15 more
TL;DR: The timsTOF Pro instrument is introduced, which optimally implements online PASEF and features an orthogonal ion path into the ion mobility device, limiting the amount of debris entering the instrument and making it very robust in daily operation.
Journal ArticleDOI
BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes
Florian Meier,Philipp E. Geyer,Philipp E. Geyer,Sebastian Virreira Winter,Juergen Cox,Matthias Mann,Matthias Mann +6 more
TL;DR: A data-acquisition method, termed BoxCar, in which filling multiple narrow mass-to-charge segments increases the mean ion injection time more than tenfold as compared to that of a standard full scan, greatly increases sensitivity and the detection of low-abundance peptides with a minimal amount of instrument time.
Journal ArticleDOI
diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition
Florian Meier,Andreas-David Brunner,Max Frank,Annie Ha,Isabell Bludau,Eugenia Voytik,Stephanie Kaspar-Schoenefeld,Markus Lubeck,Oliver Raether,Nicolai Bache,Ruedi Aebersold,Ruedi Aebersold,Ben C. Collins,Ben C. Collins,Hannes L. Röst,Matthias Mann,Matthias Mann +16 more
TL;DR: This work uses the correlation of molecular weight and ion mobility in a trapped ion mobility device to devise a scan mode that samples up to 100% of the peptide precursor ion current in m/z and mobility windows and thereby increase the specificity for precursor identification.
Journal ArticleDOI
Parallel Accumulation–Serial Fragmentation (PASEF): Multiplying Sequencing Speed and Sensitivity by Synchronized Scans in a Trapped Ion Mobility Device
Florian Meier,Scarlet Beck,Niklas Grassl,Markus Lubeck,Melvin A. Park,Oliver Raether,Matthias Mann +6 more
TL;DR: In this paper, a parallel accumulation-serial fragmentation (PASEF) method was proposed to enable hundreds of MS/MS events per second at full sensitivity for shotgun proteomics.
Journal ArticleDOI
A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics
Nicolai Bache,Philipp E. Geyer,Philipp E. Geyer,Dorte B. Bekker-Jensen,Ole Hoerning,Lasse Gaarde Falkenby,Peter V. Treit,Sophia Doll,Igor Paron,Johannes Müller,Florian Meier,Jesper V. Olsen,Ole Vorm,Matthias Mann,Matthias Mann +14 more
TL;DR: The new system - termed Evosep One - analyzes samples in an extremely robust and high throughput manner, without sacrificing in depth proteomics coverage, while maintaining the sensitivity of current nano-flow LC systems.