P
Philipp E. Geyer
Researcher at Max Planck Society
Publications - 52
Citations - 3741
Philipp E. Geyer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Proteomics & Proteome. The author has an hindex of 19, co-authored 45 publications receiving 2142 citations. Previous affiliations of Philipp E. Geyer include University of Copenhagen & Technische Universität München.
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Journal ArticleDOI
Revisiting biomarker discovery by plasma proteomics.
TL;DR: A “rectangular” plasma proteome profiling strategy is proposed, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease.
Journal ArticleDOI
Plasma Proteome Profiling to Assess Human Health and Disease.
Philipp E. Geyer,Nils A. Kulak,Garwin Pichler,Lesca M. Holdt,Daniel Teupser,Matthias Mann,Matthias Mann +6 more
TL;DR: A rapid and robust "plasma proteome profiling" pipeline is introduced that enables quantitative analysis of hundreds of plasma proteomes from 1 μl single finger pricks with 20 min gradients and functionally interpret a 1,000-protein, quantitative plasma proteome obtained by simple peptide pre-fractionation.
Journal ArticleDOI
BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes
Florian Meier,Philipp E. Geyer,Philipp E. Geyer,Sebastian Virreira Winter,Juergen Cox,Matthias Mann,Matthias Mann +6 more
TL;DR: A data-acquisition method, termed BoxCar, in which filling multiple narrow mass-to-charge segments increases the mean ion injection time more than tenfold as compared to that of a standard full scan, greatly increases sensitivity and the detection of low-abundance peptides with a minimal amount of instrument time.
Journal ArticleDOI
A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics
Nicolai Bache,Philipp E. Geyer,Philipp E. Geyer,Dorte B. Bekker-Jensen,Ole Hoerning,Lasse Gaarde Falkenby,Peter V. Treit,Sophia Doll,Igor Paron,Johannes Müller,Florian Meier,Jesper V. Olsen,Ole Vorm,Matthias Mann,Matthias Mann +14 more
TL;DR: The new system - termed Evosep One - analyzes samples in an extremely robust and high throughput manner, without sacrificing in depth proteomics coverage, while maintaining the sensitivity of current nano-flow LC systems.
Journal ArticleDOI
Region and cell-type resolved quantitative proteomic map of the human heart
Sophia Doll,M. Dreßen,Philipp E. Geyer,Philipp E. Geyer,Daniel N. Itzhak,Christian Braun,Stefanie A. Doppler,Florian Meier,Marcus-André Deutsch,Harald Lahm,Rüdiger Lange,Markus Krane,Matthias Mann,Matthias Mann +13 more
TL;DR: The authors present a region- and cell type-specific proteomic map of the healthy human heart, revealing functional differences and potential cell type markers.