Nikolas Maniatis

TL;DR: In this article, the authors present a theory to construct an additive LD map for which distances are additive and population-specific maps are expected to be approximately proportional, for a random sample and trustworthy map, which can be predicted reliably from information over a small distance and does not depend on the evolutionary variance unless the sample size approaches the population size.

TL;DR: The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain, so this analysis represents a rich resource to examine genotype-phenotype relationships in a tractable model.

TL;DR: Polymorphisms in ADAM33 predict impaired early-life lung function and there is evidence of a significant causal location between BC+1 and F1 SNPs, at the 5' end of the gene.

TL;DR: In this paper, the associations of genome-wide association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genomewide-association study derived lipid-associated SNPs with other risk factors and CHD events were evaluated.

TL;DR: The authors used a subset of single nucleotide polymorphisms from the HapMap Project to create a genome-wide map in LDU and found that recombination accounts for 96.8% of the LDU variance in chromosome arms and 92.4% in their deciles.