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Nina S. Entelis
Researcher at Moscow State University
Publications - 5
Citations - 385
Nina S. Entelis is an academic researcher from Moscow State University. The author has contributed to research in topics: Transfer RNA & Mitochondrion. The author has an hindex of 5, co-authored 5 publications receiving 378 citations. Previous affiliations of Nina S. Entelis include Centre national de la recherche scientifique.
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Journal ArticleDOI
Suppression of Mutations in Mitochondrial DNA by tRNAs Imported from the Cytoplasm
Olga Kolesnikova,Nina S. Entelis,Nina S. Entelis,Hakim Mireau,Thomas D. Fox,Robert P. Martin,Ivan Tarassov +6 more
TL;DR: It is shown that cytoplasmic tRNAs with altered aminoacylation identity can be specifically targeted to the mitochondria and participate in mitochondrial translation and that human mitochondria are able to internalize yeast tRNA derivatives in vitro and that this import requires an essential yeast import factor.
Journal ArticleDOI
An intact protein translocating machinery is required for mitochondrial import of a yeast cytoplasmic tRNA.
TL;DR: It is demonstrated that a functional mitochondrial protein translocation apparatus is required for the mitochondrial import of the yeast tRNA(LysCUU), the only nuclear-coded tRNA species to be mitochondrially-imported.
Journal ArticleDOI
Mitochondrially-imported cytoplasmic tRNA(Lys)(CUU) of Saccharomyces cerevisiae: in vivo and in vitro targetting systems.
Ivan Tarassov,Nina S. Entelis +1 more
TL;DR: Contrary to the known systems for protein transport into isolated mitochondria, mitochondrial import of tRNA(1Lys) in vitro requires the presence of soluble cellular proteins in the reaction mixture and the translocation proved to be ATP-dependent and to require the existence of an ATP-generation system in the Reaction mixture.
Journal ArticleDOI
Mitochondrial import of a yeast cytoplasmic tRNALys: possible roles of aminoacylation and modified nucleosides in subcellular partitioning
Nina S. Entelis,Nina S. Entelis,Igor A. Krasheninnikov,Robert P. Martin,Ivan Tarassov,Ivan Tarassov +5 more
TL;DR: An in vitro transcript, once aminoacylated, appeared to be a better import substrate than the natural tRNA which carries modified nucleoside modification in subcellular partitioning of the tRNA.
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The aminoacceptor stem of the yeast tRNALys contains determinants of mitochondrial import selectivity
TL;DR: Replacement of bases 1:72 in tRNALys SUU by those of tRNalys CUU makes it importable with a transport efficiency similar to natural, and shows that the first base pair (1:72) and the discriminator base 73 are also relevant to import selectivity.