Nitesh Shashikanth

TL;DR: Bead-twisting measurements andplementary investigations of cadherin-based rigidity sensing suggest that, although &agr;-catenin alters traction force generation, it is not the sole regulator of cell contractility on compliant cadhersin-coated substrata.

TL;DR: It is concluded that ZO-1–occludin interactions regulate multiple phases of epithelial polarization by providing cell-intrinsic signals that are required for single lumen formation.

TL;DR: Reduced levels of occludin and CASP3 in intestinal epithelial cells of patients with inflammatory bowel diseases might promote restoration of mucosal homeostasis in response to inflammatory conditions.

TL;DR: Micropipette manipulation measurements quantified the effect of N-glycosylation mutations on intercellular binding dynamics and suggest a binding mechanism in which initial adhesion is followed by additional cadherin interactions, which enhance binding but are modulated by N- Glycosylated interactions.

TL;DR: In vitro data suggesting that casein kinase-2 (CK2) inhibition blocks claudin-2 channel function are translated and found that CK2 inhibition prevented IL-13-induced, claud in-2-mediated permeability increases in vivo and suggest that claudIn-2 may be an accessible target in immune-mediated disorders, including inflammatory bowel disease.