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Yitang Wang
Researcher at University of Chicago
Publications - 19
Citations - 1103
Yitang Wang is an academic researcher from University of Chicago. The author has contributed to research in topics: Tight junction & Paracellular transport. The author has an hindex of 13, co-authored 19 publications receiving 706 citations.
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Journal ArticleDOI
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Marlies Meisel,Reinhard Hinterleitner,Alain Pacis,Li Chen,Zachary M. Earley,Toufic Mayassi,Joseph F. Pierre,Joseph F. Pierre,Jordan D. Ernest,Heather J. Galipeau,Nikolaus Thuille,Romain Bouziat,Manuel Buscarlet,Daina L. Ringus,Yitang Wang,Ye Li,Vu Dinh,Sangman M. Kim,Benjamin D. McDonald,Matthew A. Zurenski,Mark W. Musch,Glaucia C. Furtado,Sergio A. Lira,Gottfried Baier,Eugene B. Chang,A. Murat Eren,A. Murat Eren,Christopher R. Weber,Lambert Busque,Lucy A. Godley,Elena F. Verdu,Luis B. Barreiro,Bana Jabri +32 more
TL;DR: It is shown that bacterial translocation and increased interleukin-6 production, resulting from dysfunction of the small-intestinal barrier, are critical for the development of PMP in mice that lack Tet2 expression in haematopoietic cells.
Journal ArticleDOI
Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux
Mary M. Buschmann,Le Shen,Harsha E. Rajapakse,David R. Raleigh,Yitang Wang,Yingmin Wang,Amulya Lingaraju,Juanmin Zha,Elliot Abbott,Erin M. McAuley,Lydia A. Breskin,Licheng Wu,Kenneth Anderson,Jerrold R. Turner,Christopher R. Weber +14 more
TL;DR: Occludin loss enhances paracellular macromolecular permeability and is necessary for TNF-induced barrier loss, which requires the C-terminal OCEL domain, which stabilizes tight junction–associated occlUDin and regulates trafficking.
Journal ArticleDOI
ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.
Matthew A. Odenwald,Wangsun Choi,Aaron Buckley,Nitesh Shashikanth,Nora E. Joseph,Nora E. Joseph,Yitang Wang,Michael H. Warren,Mary M. Buschmann,Roman Pavlyuk,Jeffrey D. Hildebrand,Ben Margolis,Alan S. Fanning,Jerrold R. Turner,Jerrold R. Turner +14 more
TL;DR: It is concluded that ZO-1–occludin interactions regulate multiple phases of epithelial polarization by providing cell-intrinsic signals that are required for single lumen formation.
Journal ArticleDOI
Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression
Wei-Ting Kuo,Le Shen,Li Zuo,Li Zuo,Nitesh Shashikanth,Ma. Lora Drizella M. Ong,Licheng Wu,Juanmin Zha,Juanmin Zha,Karen L. Edelblum,Karen L. Edelblum,Yitang Wang,Yingmin Wang,Steven P. Nilsen,Jerrold R. Turner,Jerrold R. Turner +15 more
TL;DR: Reduced levels of occludin and CASP3 in intestinal epithelial cells of patients with inflammatory bowel diseases might promote restoration of mucosal homeostasis in response to inflammatory conditions.
Journal ArticleDOI
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
W. Vallen Graham,W. Vallen Graham,Wei-Qi He,Wei-Qi He,Amanda M. Marchiando,Juanmin Zha,Juanmin Zha,Gurminder Singh,Gurminder Singh,Hua-Shan Li,Amlan Biswas,Ma. Lora Drizella M. Ong,Zhi-Hui Jiang,Wangsun Choi,Harmon J. Zuccola,Yitang Wang,James P. Griffith,Jingshing Wu,Harry J. Rosenberg,Yingmin Wang,Scott B. Snapper,David A. Ostrov,Stephen C. Meredith,Lawrence W. Miller,Jerrold R. Turner,Jerrold R. Turner +25 more
TL;DR: Divertin blocks acute, tumor necrosis factor-induced MLCK1 recruitment as well as downstream myosin light chain (MLC) phosphorylation, barrier loss, and diarrhea in vitro and in vivo.