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Nora E. Joseph
Researcher at University of Chicago
Publications - 10
Citations - 422
Nora E. Joseph is an academic researcher from University of Chicago. The author has contributed to research in topics: Cancer & Graft-versus-host disease. The author has an hindex of 5, co-authored 10 publications receiving 306 citations. Previous affiliations of Nora E. Joseph include NorthShore University HealthSystem.
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Journal ArticleDOI
Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis
Sean P. Pitroda,Nikolai N. Khodarev,Lei Huang,Abhineet Uppal,Sean C. Wightman,Sabha Ganai,Nora E. Joseph,Jason J. Pitt,Miguel Brown,Martin Forde,Kathy A. Mangold,Lai Xue,Christopher R. Weber,Jeremy P. Segal,Sabah Kadri,Melinda E. Stack,Sajid A. Khan,Philip B. Paty,Karen L. Kaul,Jorge Andrade,Kevin P. White,Mark S. Talamonti,Mitchell C. Posner,Samuel Hellman,Ralph R. Weichselbaum +24 more
TL;DR: Three integrated molecular subtypes of colorectal cancer liver metastasis are identified, which complement clinical risk stratification to distinguish the subset of oligometastatic patients and provide a framework for integrated classification and treatment of metastasis.
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ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.
Matthew A. Odenwald,Wangsun Choi,Aaron Buckley,Nitesh Shashikanth,Nora E. Joseph,Nora E. Joseph,Yitang Wang,Michael H. Warren,Mary M. Buschmann,Roman Pavlyuk,Jeffrey D. Hildebrand,Ben Margolis,Alan S. Fanning,Jerrold R. Turner,Jerrold R. Turner +14 more
TL;DR: It is concluded that ZO-1–occludin interactions regulate multiple phases of epithelial polarization by providing cell-intrinsic signals that are required for single lumen formation.
Journal ArticleDOI
Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease
Sam C. Nalle,H. Aimee Kwak,Karen L. Edelblum,Nora E. Joseph,Gurminder Singh,Galina Khramtsova,Eric D. Mortenson,Peter A. Savage,Jerrold R. Turner +8 more
TL;DR: It is demonstrated that pretransplant conditioning plays a dual role in promoting minor mismatch GVHD by both depleting recipient NK cells and inducing intestinal barrier loss, demonstrating fundamental pathogenic distinctions between these forms of disease.
Journal ArticleDOI
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Sam C. Nalle,Li Zuo,Ma. Lora Drizella M. Ong,Gurminder Singh,Alicia M. Worthylake,Wangsun Choi,Mario C. Manresa,Anna P. Southworth,Karen L. Edelblum,Gregory J. Baker,Nora E. Joseph,Peter A. Savage,Jerrold R. Turner +12 more
TL;DR: Inhibition of MLCK210-dependent barrier regulation may be an effective approach to limiting GVHD progression, as indicated by reduced histopathology, fewer CD8+ effector T cells in the gut, and improved overall survival.
Journal ArticleDOI
Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.
Haibo Bai,Qingfeng Zhu,Alexandra Surcel,Tianzhi Luo,Yixin Ren,Bin Guan,Ying Liu,Nan Wu,Nora E. Joseph,Tian Li Wang,Nailing Zhang,Duojia Pan,Gianfranco Alpini,Douglas N. Robinson,Robert A. Anders +14 more
TL;DR: Using primary hepatocytes from Yap transgenic livers and Yap knockout livers, it is found that YAP antagonizes E-cadherin-mediated cell-cell junction assembly by regulating the cellular actin architecture, including its mechanical properties (elasticity and cortical tension).