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Noam Harpaz
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 223
Citations - 17160
Noam Harpaz is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Ulcerative colitis & Dysplasia. The author has an hindex of 57, co-authored 215 publications receiving 15399 citations. Previous affiliations of Noam Harpaz include New York University & Weizmann Institute of Science.
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Journal ArticleDOI
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.
Journal ArticleDOI
Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.
Roopali Bansal Gupta,Noam Harpaz,Steven H. Itzkowitz,Sabera Hossain,Sierra Matula,Asher Kornbluth,Carol A. Bodian,Thomas A. Ullman +7 more
TL;DR: The severity of microscopic inflammation over time is an independent risk factor for developing advanced colorectal neoplasia among patients with long-standing UC.
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Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors
Masayuki Fukata,Anli Chen,Arunan S. Vamadevan,Jason P. Cohen,Keith J. Breglio,Suneeta Krishnareddy,David Hsu,Ruliang Xu,Noam Harpaz,Andrew J. Dannenberg,Kotha Subbaramaiah,Harry S. Cooper,Steven H. Itzkowitz,Maria T. Abreu +13 more
TL;DR: The hypothesis that Toll-like receptor 4 (TLR4) is involved in tumorigenesis in the setting of chronic inflammation is tested and it is shown that TLR4 is overexpressed in human and murine inflammation-associated colorectal neoplasia and inhibition of TLR 4 signaling may be useful in the prevention or treatment of colitis-associated cancer.
Journal ArticleDOI
Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
Daniel N. Frank,Charles E. Robertson,Christina M. Hamm,Zegbeh Z. Kpadeh,Tianyi Zhang,Hongyan Chen,Wei Zhu,R. Balfour Sartor,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace,Ellen Li,Ellen Li +12 more
TL;DR: The concept that disease phenotype and genotype are associated with compositional changes in intestinal‐associated microbiota is supported.
Journal ArticleDOI
Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours
Rhonda F. Souza,Rebecca Appel,Jing Yin,Suna Wang,Kara N. Smolinski,John M. Abraham,Tongtong Zou,Y. Q. Shi,Junyi Lei,John R. Cottrell,Karina Cymes,Kelli G. Biden,Lisa A. Simms,Barbara A. Leggett,Patrick M. Lynch,Marsha L. Frazier,Steven M. Powell,Steven M. Powell,Noam Harpaz,Haruhiko Sugimura,Joanne P. Young,Stephen J. Meltzer +21 more
TL;DR: Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours is found to be a major cause of uncertainty in the prognosis of these tumours.