N
Norihisa Masuyama
Researcher at University of Tokyo
Publications - 35
Citations - 6652
Norihisa Masuyama is an academic researcher from University of Tokyo. The author has contributed to research in topics: Protein kinase B & Phosphorylation. The author has an hindex of 30, co-authored 35 publications receiving 6355 citations. Previous affiliations of Norihisa Masuyama include Kyoto University.
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Journal ArticleDOI
Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53 *
Yoko Ogawara,Shohei Kishishita,Toshiyuki Obata,Yuko Isazawa,Toshiaki Suzuki,Keiji Tanaka,Norihisa Masuyama,Yukiko Gotoh,Yukiko Gotoh +8 more
TL;DR: It is suggested that Akt enhances the ubiquitination-promoting function of Mdm2 by phosphorylation of Ser186, which results in reduction of p53 protein.
Journal ArticleDOI
The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells.
Yusuke Hirabayashi,Yasuhiro Itoh,Hidenori Tabata,Kazunori Nakajima,Kazunori Nakajima,Tetsu Akiyama,Norihisa Masuyama,Yukiko Gotoh,Yukiko Gotoh +8 more
TL;DR: It is shown that Wnt signaling inhibits the self-renewal capacity of mouse cortical NPCs, and instructively promotes their neuronal differentiation, and theβ -catenin/TCF complex appears to directly regulate the promoter of neurogenin 1, a gene implicated in cortical neuronal differentiation.
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JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins
Fuminori Tsuruta,Jun Sunayama,Yasunori Mori,Seisuke Hattori,Shigeomi Shimizu,Yoshihide Tsujimoto,Katsuji Yoshioka,Norihisa Masuyama,Yukiko Gotoh,Yukiko Gotoh +9 more
TL;DR: It is demonstrated that activated JNK promotes Bax translocation to mitochondria through phosphorylation of 14‐3‐3, a cytoplasmic anchor of Bax, a key mechanism of BAX regulation in stress‐induced apoptosis.
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JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates
Hiroaki Yamanaka,Tetsuo Moriguchi,Norihisa Masuyama,Morioh Kusakabe,Hiroshi Hanafusa,Ritsuko Takada,Shinji Takada,Eisuke Nishida +7 more
TL;DR: It is demonstrated that the non‐canonical Wnt/JNK pathway is conserved in both vertebrate and invertebrate and defined that JNK has an activity to regulate morphogenetic cell movements.
Journal ArticleDOI
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.
Hiroshi Hanafusa,Jun Ninomiya-Tsuji,Norihisa Masuyama,Michiru Nishita,Jun-ichi Fujisawa,Hiroshi Shibuya,Kunihiro Matsumoto,Eisuke Nishida +7 more
TL;DR: The results show that the p38 pathway is activated by TGF-β and is involved in the T GF-β-induced transcriptional activation by regulating the Smad-mediated pathway.