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Norimitsu Kadowaki
Researcher at Kagawa University
Publications - 185
Citations - 11069
Norimitsu Kadowaki is an academic researcher from Kagawa University. The author has contributed to research in topics: Cytotoxic T cell & Dendritic cell. The author has an hindex of 32, co-authored 167 publications receiving 10385 citations. Previous affiliations of Norimitsu Kadowaki include Teikyo University & Kyoto University.
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Journal ArticleDOI
The nature of the principal type 1 interferon-producing cells in human blood.
Frederick P. Siegal,Norimitsu Kadowaki,Michael Shodell,Patricia Fitzgerald-Bocarsly,Kokila Shah,Stephen Ho,Svetlana Antonenko,Yong-Jun Liu +7 more
TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.
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Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Marie-Clotilde Rissoan,Vassili Soumelis,Norimitsu Kadowaki,Géraldine Grouard,Francine Brière,Rene de Waal Malefyt,Yong-Jun Liu +6 more
TL;DR: A negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
Journal ArticleDOI
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
TL;DR: Virus-activated IPCs may play two master roles in antiviral immune responses: directly inhibiting viral replication by producing large amounts of IFN-α/β, and subsequently triggering adaptive T cell–mediated immunity by differentiating into DCs.
Journal ArticleDOI
Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN.
TL;DR: CpG DNA and polyinosinic-polycytidylic acid stimulate different types of cells to produce type I IFN and that it is important to select oligodeoxynucleotides containing particular CpG motifs to induce pre-DC2 toproduce type IIFN, which may play a key role in the strong adjuvant effects of C pG DNA.