S
Svetlana Antonenko
Researcher at Schering-Plough
Publications - 20
Citations - 13623
Svetlana Antonenko is an academic researcher from Schering-Plough. The author has contributed to research in topics: Dendritic cell & T cell. The author has an hindex of 17, co-authored 19 publications receiving 13182 citations.
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Journal ArticleDOI
A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Hervé Groux,Anne O'Garra,M. Bigler,Matthieu Rouleau,Svetlana Antonenko,Jan E. de Vries,Maria Grazia Roncarolo +6 more
TL;DR: It is shown that chronic activation of both human and murine CD4+T cells in the presence of interleukin (IL)-10 gives rise to CD4-T-cell clones with low proliferative capacity, producing high levels ofIL-10, low levels of IL-2 and no IL-4.
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The nature of the principal type 1 interferon-producing cells in human blood.
Frederick P. Siegal,Norimitsu Kadowaki,Michael Shodell,Patricia Fitzgerald-Bocarsly,Kokila Shah,Stephen Ho,Svetlana Antonenko,Yong-Jun Liu +7 more
TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.
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Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Vassili Soumelis,Pedro A. Reche,Holger Kanzler,Wei Yuan,Gina Edward,Bernhart Homey,Michel Gilliet,Steve Ho,Svetlana Antonenko,Annti Lauerma,Kathleen M. Smith,Daniel M. Gorman,Sandra Zurawski,Jon Abrams,Satish Menon,Terri McClanahan,Rene de Waal-Malefyt,Fernando Bazan,Robert A. Kastelein,Yong-Jun Liu +19 more
TL;DR: It is shown that human thymic stromal lymphopoietin (TSLP) potently activated CD11c+ dendritic cells (DCs) and induced production of the TH2-attracting chemokines TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derivedChemokine; CCL22).
Journal ArticleDOI
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
TL;DR: Virus-activated IPCs may play two master roles in antiviral immune responses: directly inhibiting viral replication by producing large amounts of IFN-α/β, and subsequently triggering adaptive T cell–mediated immunity by differentiating into DCs.