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Nynke I. Kramer
Researcher at Utrecht University
Publications - 57
Citations - 1882
Nynke I. Kramer is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 46 publications receiving 1395 citations. Previous affiliations of Nynke I. Kramer include Wageningen University and Research Centre & Swiss Federal Institute of Aquatic Science and Technology.
Papers
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Journal ArticleDOI
Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations.
Floris A. Groothuis,Minne B. Heringa,Beate Nicol,Joop L. M. Hermens,Bas J. Blaauboer,Nynke I. Kramer +5 more
TL;DR: A number of dose metrics and their dependency on in vitro assay setup are discussed, and recommendations are given on when to consider alternative dose metrics instead of nominal concentrations, in order to reduce effect concentration variability between in vitro assays and between in vivo and in vivo assays in toxicology.
Journal ArticleDOI
Predicting Adult Fish Acute Lethality with the Zebrafish Embryo: Relevance of Test Duration, Endpoints, Compound Properties, and Exposure Concentration Analysis
Melanie Knöbel,Frans J. M. Busser,Ángeles Rico-Rico,Nynke I. Kramer,Joop L. M. Hermens,Christoph Hafner,Katrin Tanneberger,Kristin Schirmer,Kristin Schirmer,Stefan Scholz +9 more
TL;DR: A very strong correlation of zebrafish embryo to fish acute toxicity is confirmed and two types of compounds were less lethal to embryos than to adult fish: a neurotoxic compound acting via sodium channels and a compound requiring metabolic activation.
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PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop.
J.G.M. Bessems,George Loizou,Kannan Krishnan,Harvey J. Clewell,Camilla Bernasconi,Frédéric Y. Bois,Sandra Coecke,Eva Maria Collnot,Walter Diembeck,Lucian Romeo Farcal,Liesbeth Geraets,Ursula Gundert-Remy,Nynke I. Kramer,Gabriele Küsters,Sofia B. Leite,Olavi Pelkonen,Klaus Schröder,Emanuela Testai,Iwona Wilk-Zasadna,José Manuel Zaldívar-Comenges +19 more
TL;DR: Five high-priority issues are presented that provide the prerequisites for wider use of non-animal based PBTK modelling for animal-free chemical risk assessment.
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Quantifying processes determining the free concentration of phenanthrene in Basal cytotoxicity assays.
TL;DR: The results indicate that the free concentration of phenanthrene, a relatively volatile and hydrophobic compound, is significantly reduced in a typical in vitro setup as it binds to matrices such as serum protein and well plate plastic.
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The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
Bas J. Blaauboer,Kim Boekelheide,Harvey J. Clewell,Mardas Daneshian,Milou M.L. Dingemans,Alan M. Goldberg,Marjoke Heneweer,Joanna Jaworska,Nynke I. Kramer,Marcel Leist,Hasso Seibert,Emanuela Testai,Rob J. Vandebriel,James D. Yager,Joanne Zurlo +14 more
TL;DR: A conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process and the determination of a proper point-of-departure (PoD) forIn vitro-in vivo extrapolation, allowing implementation in risk assessment procedures.