O
Oihana Terrones
Researcher at University of the Basque Country
Publications - 16
Citations - 1269
Oihana Terrones is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Cardiolipin & Mitochondrion. The author has an hindex of 9, co-authored 13 publications receiving 1134 citations. Previous affiliations of Oihana Terrones include University of Geneva.
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Journal ArticleDOI
Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
Sylvie Montessuit,Syam Prakash Somasekharan,Oihana Terrones,Safa Lucken-Ardjomande,Sébastien Herzig,Robert Schwarzenbacher,Dietmar J. Manstein,Ella Bossy-Wetzel,Gorka Basañez,Paolo Meda,Jean-Claude Martinou +10 more
TL;DR: It is shown that Drp1 stimulates tBid-induced Bax oligomerization and cytochrome c release by promoting tethering and hemifusion of membranes in vitro by exploiting arginine 247 and the presence of cardiolipin in membranes.
Journal ArticleDOI
Lipidic pore formation by the concerted action of proapoptotic BAX and tBID
Oihana Terrones,Bruno Antonsson,Hirohito Yamaguchi,Hong Gang Wang,Jihua Liu,Ray M. Lee,Andreas Herrmann,Gorka Basañez +7 more
TL;DR: A novel model is proposed in which tBID assists BAX not only viaprotein-protein but also via protein-lipid interactions to form lipidic pore-type non-bilayer structures in the outer mitochondrial membrane through which intermembrane prodeath molecules exit mitochondria during apoptosis.
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Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma
Joan Montero,Albert Morales,Laura Llacuna,Josep M. Lluis,Oihana Terrones,Gorka Basañez,Bruno Antonsson,Jesús Prieto,Carmen García-Ruiz,Anna Colell,José C. Fernández-Checa +10 more
TL;DR: Mitochondria from rat or human hepatocellular carcinoma (HC) cells (HCC) or primary tumors from patients with HC exhibit increased mitochondrial cholesterol levels, which contributes to chemotherapy resistance by increasing membrane order.
Journal ArticleDOI
Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1.
Itsasne Bustillo-Zabalbeitia,Sylvie Montessuit,Etienne Raemy,Gorka Basañez,Oihana Terrones,Jean-Claude Martinou +5 more
TL;DR: It is found that Drp1 can interact with pure lipid bilayers enriched in the mitochondrion-specific phospholipid cardiolipin (CL), and it is shown that a four lysine module located within the B insert ofDrp1 interacts preferentially with CL over other anionic lipids.
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Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation
Montserrat Marí,Anna Colell,Albert Morales,Francisco Caballero,Anna Moles,Anna Fernández,Oihana Terrones,Gorka Basañez,Bruno Antonsson,Carmen García–Ruiz,José C. Fernández–Checa +10 more
TL;DR: MOM-localized oligomeric Bax is not sufficient for TNF-induced MOM permeabilization and cell death requiring mGSH-controlled ASMase-mediated mitochondrial membrane remodeling by oxidized cardiolipin generation.