R
Robert Schwarzenbacher
Researcher at University of Salzburg
Publications - 57
Citations - 5712
Robert Schwarzenbacher is an academic researcher from University of Salzburg. The author has contributed to research in topics: Thermotoga maritima & Mitochondrial fission. The author has an hindex of 28, co-authored 57 publications receiving 5278 citations. Previous affiliations of Robert Schwarzenbacher include San Diego Supercomputer Center & University of California, San Diego.
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Mitochondrial fragmentation in neurodegeneration
TL;DR: Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. as discussed by the authors showed that mutations in the mitochondrial fusion GTPases mitofusin 2 and optic atrophy 1, neurotoxins and oxidative stress all disrupt the cable-like morphology of functional mitochondria.
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Molecular pathways to neurodegeneration
TL;DR: The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed as mentioned in this paper, and the problem that investigators face is distinguishing primary from secondary events is to distinguish primary events.
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Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Wenjun Song,Jin-jin Chen,Alejandra M. Petrilli,Géraldine Liot,Eva Klinglmayr,Yue-Yue Zhou,Patrick Poquiz,Jonathan Tjong,Mahmoud A. Pouladi,Michael R. Hayden,Eliezer Masliah,Mark H. Ellisman,Isabelle Rouiller,Robert Schwarzenbacher,Blaise Bossy,Guy Perkins,Ella Bossy-Wetzel +16 more
TL;DR: It is shown that mutant huntingtin triggers mitochondrial fragmentation in rat neurons and fibroblasts of individuals with Huntington's disease in vitro and in a mouse model of Huntington’s disease in vivo before the presence of neurological deficits and huntingtin aggregates.
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OPA1 mutations induce mitochondrial DNA instability and optic atrophy plus phenotypes
Patrizia Amati-Bonneau,Maria Lucia Valentino,Pascal Reynier,María Esther Gallardo,Belén Bornstein,Anne Boissiere,Yolanda Campos,Henry Rivera,Jesús González de la Aleja,Rosanna Carroccia,Luisa Iommarini,Pierre Labauge,Dominique Figarella-Branger,Pascale Marcorelles,Alain Furby,Katell Beauvais,Franck Letournel,Rocco Liguori,Chiara La Morgia,Pasquale Montagna,Maria Liguori,Claudia Zanna,Michela Rugolo,Andrea Cossarizza,Bernd Wissinger,Christophe Verny,Robert Schwarzenbacher,Miguel A. Martín,Joaquiotan Arenas,Carmen Ayuso,Rafael Garesse,Guy Lenaers,Dominique Bonneau,Valerio Carelli +33 more
TL;DR: In this paper, mutations in the OPA1 gene can also be responsible for a syndromic form of DOA associated with sensorineural deafness, ataxia, axonal sensory-motor polyneuropathy, chronic progressive external ophthalmoplegia and mitochondrial myopathy.
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Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
Sylvie Montessuit,Syam Prakash Somasekharan,Oihana Terrones,Safa Lucken-Ardjomande,Sébastien Herzig,Robert Schwarzenbacher,Dietmar J. Manstein,Ella Bossy-Wetzel,Gorka Basañez,Paolo Meda,Jean-Claude Martinou +10 more
TL;DR: It is shown that Drp1 stimulates tBid-induced Bax oligomerization and cytochrome c release by promoting tethering and hemifusion of membranes in vitro by exploiting arginine 247 and the presence of cardiolipin in membranes.