O
Olga B Botvinnik
Researcher at Massachusetts Institute of Technology
Publications - 7
Citations - 156
Olga B Botvinnik is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Lenalidomide & Haematopoiesis. The author has an hindex of 4, co-authored 7 publications receiving 143 citations. Previous affiliations of Olga B Botvinnik include Harvard University.
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Journal ArticleDOI
Characterizing genomic alterations in cancer by complementary functional associations
Jong Wook Kim,Jong Wook Kim,Olga B Botvinnik,Omar O. Abudayyeh,Omar O. Abudayyeh,Chet Birger,Joseph Rosenbluh,Joseph Rosenbluh,Yashaswi Shrestha,Yashaswi Shrestha,Mohamed E. Abazeed,Mohamed E. Abazeed,Peter S. Hammerman,Peter S. Hammerman,Daniel DiCara,David J. Konieczkowski,David J. Konieczkowski,Cory M. Johannessen,Cory M. Johannessen,Arthur Liberzon,Amir Reza Alizad-Rahvar,Gabriela Alexe,Andrew J. Aguirre,Andrew J. Aguirre,Mahmoud Ghandi,Heidi Greulich,Heidi Greulich,Heidi Greulich,Francisca Vazquez,Francisca Vazquez,Barbara A. Weir,Eliezer M. Van Allen,Eliezer M. Van Allen,Aviad Tsherniak,Diane D. Shao,Diane D. Shao,Travis I. Zack,Travis I. Zack,Michael S. Noble,Gad Getz,Rameen Beroukhim,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Masoud Ardakani,Chiara Romualdi,Gabriele Sales,David A. Barbie,David A. Barbie,Jesse S. Boehm,William C. Hahn,Jill P. Mesirov,Jill P. Mesirov,Pablo Tamayo,Pablo Tamayo +54 more
TL;DR: REVEALER successfully identified both known and new associations, demonstrating the power of combining functional profiles with extensive characterization of genomic alterations in cancer genomes.
Journal ArticleDOI
MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Kris C. Wood,David J. Konieczkowski,David J. Konieczkowski,Cory M. Johannessen,Cory M. Johannessen,Jesse S. Boehm,Pablo Tamayo,Olga B Botvinnik,Jill P. Mesirov,William C. Hahn,William C. Hahn,David E. Root,Levi A. Garraway,Levi A. Garraway,David M. Sabatini +14 more
TL;DR: The MicroSCALE platform described here may enable new classes of large-scale, resource-efficient screens that were not previously feasible, including those involving combinations of cell lines, perturbations, and assay outputs or those involving limited numbers of cells and limited or expensive reagents.
Journal ArticleDOI
Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome
Naomi Galili,Pablo Tamayo,Olga B Botvinnik,Jill P. Mesirov,Margarita R Brooks,Gail L. Brown,Azra Raza +6 more
TL;DR: In this paper, the authors used gene expression profiling and grouping by response to construct a predictive score that indicates the likelihood that patients without deletion 5q will respond to lenalidomide.
Computational analysis of single-cell alternative splicing
TL;DR: Systematic AS characterization in single cells redefines the understanding of AS complexity in cell biology and generates isoform diversity critical for cellular identity and homeostasis in multicellular life.
MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Kris C. Wood,David J. Konieczkowski,David J. Konieczkowski,Cory M. Johannessen,Cory M. Johannessen,Jesse S. Boehm,Pablo Tamayo,Olga B Botvinnik,Jill P. Mesirov,William C. Hahn,William C. Hahn,David E. Root,Levi A. Garraway,Levi A. Garraway,David M. Sabatini +14 more
TL;DR: The Broad Institute of MIT and Harvard (Scientific Planning and Allocation of Resources Committee Grant) as discussed by the authors was the first grant to support the work presented in this paper, which is available online.