Alice Vickers

TL;DR: The results provide the first comprehensive characterization of coordinated DNA methylation and gene expression markers of smoking in adipose tissue and give insights into understanding the widespread health consequence of smoking outside of the lung.

TL;DR: In this article, a robust in vitro platform for high-content screening of multiple human pluripotent stem cell (hPSC) lines for their ability to undergo peri-gastrulation-like fate patterning upon bone morphogenetic protein 4 (BMP4) treatment of geometrically confined colonies and observed significant heterogeneity in their differentiation propensities along a gastrulation associable and neuralization associable axis.

TL;DR: In this article , spatial transcriptomics and stem-cell-based embryo models were used to reveal the molecular code of lineage specification in the primate embryo and provide an in vivo reference to decipher human development.

TL;DR: This study establishes a strategy for examining the genetic basis of inter-individual variability in cell behavior and identifies genes that correlate in expression with intrinsic and extrinsic PEER factors and associate outlier cell behavior with genes containing rare deleterious non-synonymous SNVs.

TL;DR: The results provide the first comprehensive characterization of coordinated DNA methylation and gene expression markers of smoking in adipose tissue, a subset of which link to human cardio-metabolic health and may give insights into the wide ranging risk effects of smoking across the body.