O
Ovijit Chaudhuri
Researcher at Stanford University
Publications - 80
Citations - 13181
Ovijit Chaudhuri is an academic researcher from Stanford University. The author has contributed to research in topics: Self-healing hydrogels & Extracellular matrix. The author has an hindex of 34, co-authored 70 publications receiving 9310 citations. Previous affiliations of Ovijit Chaudhuri include University of California, San Francisco & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Highly stretchable and tough hydrogels
Jeong-Yun Sun,Xuanhe Zhao,Widusha R. K. Illeperuma,Ovijit Chaudhuri,Kyu Hwan Oh,David J. Mooney,David J. Mooney,Joost J. Vlassak,Zhigang Suo +8 more
TL;DR: The synthesis of hydrogels from polymers forming ionically and covalently crosslinked networks is reported, finding that these gels’ toughness is attributed to the synergy of two mechanisms: crack bridging by the network of covalent crosslinks, and hysteresis by unzipping thenetwork of ionic crosslinks.
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Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Ovijit Chaudhuri,Ovijit Chaudhuri,Ovijit Chaudhuri,Luo Gu,Luo Gu,Darinka D. Klumpers,Darinka D. Klumpers,Darinka D. Klumpers,Max Darnell,Max Darnell,Sidi A. Bencherif,Sidi A. Bencherif,James C. Weaver,Nathaniel Huebsch,Hong-pyo Lee,Evi Lippens,Evi Lippens,Georg N. Duda,David J. Mooney,David J. Mooney +19 more
TL;DR: It is found that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) are all enhanced in cells cultured in gels with faster relaxation, highlighting stress relaxation as a key characteristic of cell-ECM interactions and as an important design parameter of biomaterials for cell culture.
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Effects of extracellular matrix viscoelasticity on cellular behaviour.
TL;DR: The role of viscoelasticity of tissues and extracellular matrices in cell–matrix interactions and mechanotransduction and the potential utility of vis coelastic biomaterials in regenerative medicine are explored.
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Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
Ovijit Chaudhuri,Sandeep T. Koshy,Cristiana Branco da Cunha,Jae-Won Shin,Catia S. Verbeke,Kimberly H. Allison,David J. Mooney +6 more
TL;DR: It is demonstrated that interpenetrating networks of reconstituted basement membrane matrix and alginate can be used to modulate ECM stiffness independently of composition and architecture.
Journal ArticleDOI
Substrate stress relaxation regulates cell spreading
Ovijit Chaudhuri,Luo Gu,Max Darnell,Darinka D. Klumpers,Sidi A. Bencherif,James C. Weaver,Nathaniel Huebsch,David J. Mooney +7 more
TL;DR: Surprisingly, both the computational model and experiments find that spreading for cells cultured on soft substrates that exhibit stress relaxation is greater than cells spreading on elastic substrates of the same modulus, but similar to that of cells spread on stiffer elastic substrate.