O
Owen W. Griffith
Researcher at Medical College of Wisconsin
Publications - 152
Citations - 17453
Owen W. Griffith is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Nitric oxide & Glutathione. The author has an hindex of 51, co-authored 152 publications receiving 16958 citations. Previous affiliations of Owen W. Griffith include Duke University & University of Texas System.
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Journal ArticleDOI
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
TL;DR: It is reported here that 2-vinylpyridine is a much better reagent for the derivitization of glutathione, and it is demonstrated that the total glutATHione concentration in mouse plasma is substantially higher than generally reported and that glutathion disulfide constitutes less than 30% of the totalglutathione present.
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Nitric Oxide Synthases: Properties and Catalytic Mechanism
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Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TL;DR: Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.
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NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.
Robert G. Kilbourn,Steven S. Gross,Amal Jubran,James Adams,Owen W. Griffith,Roberto Levi,Robert F Lodato +6 more
TL;DR: It is suggested that excessive nitric oxide production mediates the hypotensive effect of TNF, a potent vasodilator initially characterized as endothelium-derived relaxing factor.
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N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
Dennis J. Stuehr,Nyoun Soo Kwon,Carl Nathan,Owen W. Griffith,Paul L. Feldman,Jeffrey Wiseman +5 more
TL;DR: Results support a mechanism in which N omega-hydroxy-L-arginine is generated as an intermediate in nitric oxide (.NO) synthesis through an NADPH-dependent hydroxylation of L-argInine.