P
P. Sivaramakrishna Rachakonda
Researcher at German Cancer Research Center
Publications - 28
Citations - 3130
P. Sivaramakrishna Rachakonda is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Telomerase reverse transcriptase & Melanoma. The author has an hindex of 20, co-authored 28 publications receiving 2752 citations. Previous affiliations of P. Sivaramakrishna Rachakonda include Free University of Berlin & Humboldt State University.
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Journal ArticleDOI
TERT Promoter Mutations in Familial and Sporadic Melanoma
Susanne Horn,Adina Figl,P. Sivaramakrishna Rachakonda,Christine Fischer,Antje Sucker,Andreas Gast,Stephanie Kadel,Iris Moll,Eduardo Nagore,Kari Hemminki,Kari Hemminki,Dirk Schadendorf,Rajesh Kumar +12 more
TL;DR: A melanoma-prone family through linkage analysis and high-throughput sequencing was investigated and a disease-segregating germline mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomersase, caused up to twofold increase in transcription.
Journal ArticleDOI
TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism
P. Sivaramakrishna Rachakonda,Ismail Hosen,Petra J. de Verdier,Mahdi Fallah,Barbara Heidenreich,Charlotta Ryk,N. Peter Wiklund,Gunnar Steineck,Gunnar Steineck,Dirk Schadendorf,Kari Hemminki,Kari Hemminki,Rajesh Kumar +12 more
TL;DR: It is shown that the telomerase reverse transcriptase (TERT) promoter mutations, which create de novo E-twenty six/ternary complex factors (Ets/TCF) transcription binding sites, influence both survival and recurrence in bladder cancer patients.
Journal ArticleDOI
TERT promoter mutations in cancer development.
TL;DR: The newly described germline and recurrent somatic mutations in melanoma and other cancers in the TERT promoter that create de novo E-twenty six/ternary complex factors (Ets/TCF) binding sites, provide an insight into the possible cause of tumor-specific increased TERT expression.
Journal ArticleDOI
Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.
Barbara Heidenreich,Eduardo Nagore,P. Sivaramakrishna Rachakonda,Zaida García-Casado,Celia Requena,Victor Traves,Jürgen C. Becker,Nadem Soufir,Kari Hemminki,Rajesh Kumar +9 more
TL;DR: It is shown that the TERT promoter mutations, besides causing an increased gene expression, associate with increased patient age, increased Breslow thickness and tumour ulceration in 287 primary melanomas.
Journal ArticleDOI
Somatic mutations in exocrine pancreatic tumors: association with patient survival.
P. Sivaramakrishna Rachakonda,Andrea S. Bauer,Huaping Xie,Huaping Xie,Daniele Campa,Cosmeri Rizzato,Federico Canzian,Stefania Beghelli,William Greenhalf,Eithne Costello,Michaela Schanne,Anette Heller,Aldo Scarpa,John P. Neoptolemos,Jens Werner,Markus W. Büchler,Jörg D. Hoheisel,Kari Hemminki,Kari Hemminki,Nathalia A. Giese,Rajesh Kumar +20 more
TL;DR: The results are indicative of an association between mutational status and survival in PDAC patients, which if confirmed in subsequent studies can have potential clinical application.