E
Eithne Costello
Researcher at University of Liverpool
Publications - 152
Citations - 8775
Eithne Costello is an academic researcher from University of Liverpool. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 47, co-authored 135 publications receiving 7309 citations. Previous affiliations of Eithne Costello include University of Lausanne & National Institute for Health Research.
Papers
More filters
Journal ArticleDOI
Therapeutic developments in pancreatic cancer: current and future perspectives.
John P. Neoptolemos,Jörg Kleeff,Jörg Kleeff,Patrick Michl,Eithne Costello,William Greenhalf,Daniel H. Palmer +6 more
TL;DR: The improvements in pancreatic cancer treatment obtained in the past few years are explored, key questions related to the future development of new therapies are discussed and where successes are likely to be achieved in the future are addressed.
Journal ArticleDOI
Circulating microRNAs as potential markers of human drug‐induced liver injury
Philip J. Starkey Lewis,James W. Dear,Vivien Platt,Kenneth J. Simpson,Darren G. Craig,Daniel J. Antoine,Neil French,Neeraj Dhaun,David J. Webb,Eithne Costello,John P. Neoptolemos,Jonathan G. Moggs,Christopher E. Goldring,B. Kevin Park +13 more
TL;DR: This work provides the first evidence for the potential use of miRNAs as biomarkers of human drug‐induced liver injury by examining these molecules, for the first time, in humans with APAP poisoning.
Journal ArticleDOI
Biology and management of pancreatic cancer
TL;DR: A more sophisticated approach to palliative care and the centralisation of pancreatic cancer services is leading to greater tumour resection rates and newer adjuvant modalities are also greatly increasing the 5 year survival rates.
Journal ArticleDOI
Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial
William Greenhalf,Paula Ghaneh,John P. Neoptolemos,Daniel H. Palmer,Trevor Cox,Richard F. Lamb,Elizabeth Garner,Fiona Campbell,John R. Mackey,Eithne Costello,Malcolm J. Moore,Juan W. Valle,A. C. McDonald,Ross Carter,Ross Carter,Niall C. Tebbutt,David Goldstein,Jennifer Shannon,Christos Dervenis,Bengt Glimelius,Mark Deakin,Richard Charnley,François Lacaine,Andrew Scarfe,Mark R. Middleton,Alan Anthoney,Christopher Halloran,Julia Mayerle,Attila Oláh,Richard J. Jackson,Charlotte L. Rawcliffe,Aldo Scarpa,Claudio Bassi,Markus W. Büchler +33 more
TL;DR: Subject to prospective validation, gemcitabine should not be used for patients with low tumor hENT1 expression.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Brian M. Wolpin,Cosmeri Rizzato,Peter Kraft,Charles Kooperberg,Gloria M. Petersen,Zhaoming Wang,Alan A. Arslan,Laura Beane-Freeman,Paige M. Bracci,Julie E. Buring,Federico Canzian,Eric J. Duell,Steven Gallinger,Graham G. Giles,Gary E. Goodman,Phyllis J. Goodman,Eric J. Jacobs,Aruna Kamineni,Alison P. Klein,Laurence N. Kolonel,Matthew H. Kulke,Donghui Li,Núria Malats,Sara H. Olson,Harvey A. Risch,Howard D. Sesso,Howard D. Sesso,Kala Visvanathan,Emily White,Emily White,Wei Zheng,Christian C. Abnet,Demetrius Albanes,Gabriella Andreotti,Melissa A. Austin,Richard Barfield,Daniela Basso,Sonja I. Berndt,Marie-Christine Boutron-Ruault,Michelle Brotzman,Markus W. Büchler,H. Bas Bueno-de-Mesquita,Peter Bugert,Laurie Burdette,Daniele Campa,Neil E. Caporaso,Gabriele Capurso,Charles C. Chung,Michelle Cotterchio,Eithne Costello,Joanne W. Elena,Niccola Funel,J. Michael Gaziano,J. Michael Gaziano,J. Michael Gaziano,Nathalia Giese,Edward Giovannucci,Michael Goggins,Megan J. Gorman,Myron D. Gross,Christopher A. Haiman,Manal M. Hassan,Kathy J. Helzlsouer,Brian E. Henderson,Elizabeth A. Holly,Nan Hu,David J. Hunter,Federico Innocenti,Mazda Jenab,Rudolf Kaaks,Timothy J. Key,Kay-Tee Khaw,Eric A. Klein,Manolis Kogevinas,Vittorio Krogh,Juozas Kupcinskas,Robert C. Kurtz,Andrea Z. LaCroix,Maria Teresa Landi,Stefano Landi,Loic Le Marchand,Andrea Mambrini,Satu Männistö,Roger L. Milne,Yusuke Nakamura,Ann L. Oberg,Kouros Owzar,Alpa V. Patel,Petra H.M. Peeters,Petra H.M. Peeters,Ulrike Peters,Raffaele Pezzilli,Ada Piepoli,Miquel Porta,Miquel Porta,Francisco X. Real,Francisco X. Real,Elio Riboli,Nathaniel Rothman,Aldo Scarpa,Xiao-Ou Shu,Debra T. Silverman,Pavel Soucek,Malin Sund,Renata Talar-Wojnarowska,Philip R. Taylor,George Theodoropoulos,Mark D. Thornquist,Anne Tjønneland,Geoffrey S. Tobias,Dimitrios Trichopoulos,Pavel Vodicka,Jean Wactawski-Wende,Nicolas Wentzensen,Chen Wu,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Robert N. Hoover,Patricia Hartge,Charles S. Fuchs,Stephen J. Chanock,Rachael S. Stolzenberg-Solomon,Laufey T. Amundadottir +123 more
TL;DR: This study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies and an independent signal in exon 2 of TERT at the established region 5p15.