Pablo E. Visconti

TL;DR: It is shown that glucose consumption is enhanced in media that support mouse sperm capacitation suggesting upregulation of glucose metabolic pathways and cAMP and calcium pathways are involved in the regulation of glycolytic energy pathways during murine sperm capacitate.

TL;DR: It is found that sperm from patients who repeatedly failed ICSI were unable to induce egg activation and are, therefore, sterile.

TL;DR: The established role of TSSKs in spermiogenesis and in male fertility, together with their unique kinase features, strongly supports this family of protein kinases as a very promising drug discovery target for development of a non-hormonal male contraceptive.

TL;DR: It is found that sperm incubation in diffusible substances of the jelly coat (egg water) for 90-180 s is sufficient to render sperm transiently capable of fertilizing dejellied oocytes, indicating that sperm should undergo a series of molecular changes to gain fertilizing capacity.

TL;DR: It is shown that injected bovine sperm are resistant to nuclear decondensation by in vitro-matured oocytes and this deficiency cannot be simply overcome by exogenous activation protocols, even by inducing physiological calcium oscillations, and the inability of a suboptimal ooplasmic environment to induce sperm head Decondensation limits the success of ICSI in the bovines.