Pallu Reddanna

TL;DR: The role of cyclooxygenase-2 in primitive neuroectodermal tumor (PNET) the most malignant brain tumors of childhood was investigated and the effect of selective COX-2 inhibitors, celecoxib and rofecoxib on the growth of two PNET cell lines was determined.

TL;DR: Recent experimental evidences are focused on to support the notion that PLA2s are causally implicated in the pathobiology of cancer and inflammatory related disorders and discuss the potential utility of isoform specific PLA2 inhibitors as preventive and/or therapeutic agents.

TL;DR: In vivo and in vitro studies suggest that BHUx is acting mainly at three levels, i.e., as a potent natural antioxidant, by reduction of key inflammatory mediators of arachidonic acid cascade and by preventing 15-LOX-mediated LDL oxidations, to prevent atherosclerosis.

TL;DR: No signals were recorded in the lung tissue of vitamin E- and Se-supplemented animals, when subjected to a similar exercise program, suggesting that protection is offered by vitamin E and Se in combating oxidative stress.

TL;DR: Analysis of the endogenous LOX metabolites in pigeonpea seedlings revealed the predominant formation of 13-hydroperoxyoctadecadienoic acid in healthy seedlings and 13-HPOTrE in infected seedlings, which showed that HPOTrEs, LOX metabolites of α-linolenic acid, are more anti-fungal compared to HPODEs,LOX metabolites of linoleic acid.