P
Pamela Della Mina
Researcher at University of Milano-Bicocca
Publications - 15
Citations - 1251
Pamela Della Mina is an academic researcher from University of Milano-Bicocca. The author has contributed to research in topics: Transplantation & Haematopoiesis. The author has an hindex of 11, co-authored 15 publications receiving 1077 citations. Previous affiliations of Pamela Della Mina include University of Milan.
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Journal ArticleDOI
Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy
Valentina Ciravolo,Veronica Huber,Gaia C. Ghedini,Elisabetta Venturelli,Francesca Bianchi,Manuela Campiglio,Daniele Morelli,Antonello Villa,Pamela Della Mina,Sylvie Ménard,Paola Filipazzi,Licia Rivoltini,Elda Tagliabue,Serenella M. Pupa +13 more
TL;DR: Findings point to the role of Her2‐positive exosomes in modulating sensitivity to Trastuzumab, and, consequently, to HER2‐driven tumor aggressiveness.
Journal ArticleDOI
pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity.
Angelo De Milito,Rossella Canese,Maria Marino,Martina Borghi,Manuela Iero,Antonello Villa,Giulietta Venturi,Francesco Lozupone,Elisabetta Iessi,Mariantonia Logozzi,Pamela Della Mina,Mario Santinami,Monica Rodolfo,Franca Podo,Licia Rivoltini,Stefano Fais +15 more
TL;DR: Preclinical evidence supporting the use of PPI as novel therapeutic strategy for melanoma is shown, providing the proof of concept that PPI target human melanoma modifying tumor pH gradients.
Journal ArticleDOI
TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site
Licia Rivoltini,Claudia Chiodoni,Paola Squarcina,Monica Tortoreto,Antonello Villa,Barbara Vergani,Maja Bürdek,Laura Botti,Ivano Arioli,Agata Cova,Giorgio Mauri,Elisabetta Vergani,Beatrice Bianchi,Pamela Della Mina,Laura Cantone,Valentina Bollati,Nadia Zaffaroni,Alessandro Massimo Gianni,Mario P. Colombo,Veronica Huber +19 more
TL;DR: TRAIL-armed exosomes can induce apoptosis in cancer cells and control tumor progression in vivo, and represent a promising therapeutic tool in cancer.
Journal ArticleDOI
Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation.
Erica Dander,Adriana Balduzzi,Greta Zappa,Giovanna Lucchini,Paolo Perseghin,Valentina Andre,Elisabetta Todisco,Daoud Rahal,Maddalena Migliavacca,Daniela Longoni,Graziella Solinas,Antonello Villa,Emilio Berti,Pamela Della Mina,Matteo Parma,Paola Allavena,Ettore Biagi,Attilio Rovelli,Andrea Biondi,Giovanna D'Amico +19 more
TL;DR: The hypothesis that T-helper (TH)-17 cells are involved in the active phases of GVHD and may represent a novel cellular target for developing new strategies for GV HD treatment is supported.
Journal ArticleDOI
Heterogeneous phenotype of human melanoma cells with in vitro and in vivo features of tumor-initiating cells.
Michela Perego,Monica Tortoreto,Gabrina Tragni,Luigi Mariani,Paola Deho,Antonino Carbone,Mario Santinami,Roberto Patuzzo,Pamela Della Mina,Antonello Villa,Graziella Pratesi,Giacomo Cossa,Paola Perego,Maria Grazia Daidone,Malcolm R. Alison,Giorgio Parmiani,Licia Rivoltini,Chiara Castelli +17 more
TL;DR: The data provide further evidence on the heterogeneous nature of human melanomas and show that melanospheres and their corresponding tumors, which are generated in vivo in immunocompromised mice, represent a model to investigate melanoma biology.