Pamela V. Chang

TL;DR: A Cu-free variant of click chemistry that can label biomolecules rapidly and selectively in living systems, overcoming the intrinsic toxicity of the canonical Cu-catalyzed reaction is reported.

TL;DR: It is demonstrated that the short-chain fatty acid n-butyrate, which is secreted in high amounts by commensal bacteria, can modulate the function of intestinal macrophages, the most abundant immune cell type in the lamina propria, and elucidate a pathway in which the host may maintain tolerance to intestinal microbiota by rendering lamina Propria macrophage hyporesponsive to commensals through the down-regulation of proinflammatory effectors.

TL;DR: Cu-free click chemistry is established as a bioorthogonal reaction that can be executed in the physiologically relevant context of a mouse for labeling biomolecules in live mice.

TL;DR: It is discovered that three gut microbially produced, small-molecule metabolites, which derive from dietary tryptophan, improve intestinal barrier integrity and protect against inflammation caused by IBDs.

TL;DR: N-(4-pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.