P
Pamela Z. New
Researcher at Houston Methodist Hospital
Publications - 6
Citations - 668
Pamela Z. New is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Temozolomide & Glioma. The author has an hindex of 5, co-authored 6 publications receiving 412 citations.
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Journal ArticleDOI
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.
Linda M. Liau,Keyoumars Ashkan,David Tran,Jian Campian,John E. Trusheim,Charles S. Cobbs,Jason Heth,Michael Salacz,Sarah A. Taylor,Stacy D. D’Andre,Fabio M. Iwamoto,Edward J. Dropcho,Yaron A. Moshel,Kevin A. Walter,Clement Pillainayagam,Robert Aiken,Rekha Chaudhary,Samuel Goldlust,Daniela A. Bota,Paul Duic,Jai Grewal,Heinrich Elinzano,Steven A. Toms,Kevin O. Lillehei,Tom Mikkelsen,Tobias Walbert,Steven R. Abram,Andrew Brenner,Steven Brem,Matthew G. Ewend,Simon Khagi,Jana Portnow,Lyndon Kim,William G. Loudon,Reid C. Thompson,David Avigan,Karen Fink,Francois J. Geoffroy,Scott Lindhorst,Jose Lutzky,Andrew E. Sloan,Gabriele Schackert,Dietmar Krex,Hans-Jorg Meisel,Julian Wu,Raphael P. Davis,Christopher Duma,Arnold B. Etame,David Mathieu,Santosh Kesari,David Piccioni,Manfred Westphal,David S. Baskin,Pamela Z. New,Michel Lacroix,Sven-Axel May,Timothy J. Pluard,Victor Tse,Richard M. Green,John L. Villano,Michael Pearlman,Kevin Petrecca,Michael Schulder,Lynne Taylor,Anthony E. Maida,Robert M. Prins,Timothy F. Cloughesy,Paul Mulholland,Marnix L. Bosch +68 more
TL;DR: Addition of DCVax-L to standard therapy is feasible and safe in glioblastoma patients, and may extend survival, and overall adverse events withDCVax were comparable to standard Therapy alone.
Journal ArticleDOI
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma
E. Antonio Chiocca,Laura K. Aguilar,Susan Bell,Balveen Kaur,Jayson Hardcastle,Robert Cavaliere,John M. McGregor,Simon S. Lo,Abhik Ray-Chaudhuri,Arnab Chakravarti,John C. Grecula,Herbert B. Newton,Kimbra S. Harris,Robert G. Grossman,Todd Trask,David S. Baskin,Carissa Monterroso,Andrea G. Manzanera,Estuardo Aguilar-Cordova,Pamela Z. New +19 more
TL;DR: AdV-tk plus valacyclovir can be safely delivered with surgery and accelerated radiation in newly diagnosed malignant gliomas and MGMT independence trends are encouraging, although not powered for efficacy.
Journal ArticleDOI
Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
Lee A. Wheeler,Andrea G. Manzanera,Susan Bell,Robert Cavaliere,John M. McGregor,John C. Grecula,Herbert B. Newton,Simon S. Lo,Behnam Badie,Jana Portnow,Bin S. Teh,Todd Trask,David S. Baskin,Pamela Z. New,Laura K. Aguilar,Estuardo Aguilar-Cordova,E. Antonio Chiocca +16 more
TL;DR: Survival outcomes were most notably improved in patients with minimal residual disease after gross total resection, suggesting GMCI can be safely combined with SOC in newly diagnosed malignant gliomas.
Journal ArticleDOI
Phase II multicenter study of gene mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
Laura K. Aguilar,Lee A. Wheeler,Andrea G. Manzanera,Susan Bell,Robert Cavaliere,John M. McGregor,Simon S. Lo,John C. Grecula,Herbert B. Newton,Behnam Badie,Todd Trask,David S. Baskin,Jana Portnow,Pamela Z. New,Estuardo Aguilar-Cordova,E. Antonio Chiocca +15 more
TL;DR: Gene Mediated Cytotoxic Immunotherapy generates a polyvalent anti-tumor immune response through local delivery of aglatimagene besadenovec plus prodrug, synergizing with SOC to improve patient outcomes.
Journal ArticleDOI
Correction: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma [J Transl Med., 16, (2018) (142)] DOI: 10.1186/s12967-018-1507-6
Linda M. Liau,Keyoumars Ashkan,David Tran,Jian Campian,John E. Trusheim,Charles S. Cobbs,Jason Heth,Michael Salacz,Sarah A. Taylor,Stacy D. D’Andre,Fabio M. Iwamoto,Edward J. Dropcho,Yaron A. Moshel,Kevin A. Walter,Clement Pillainayagam,Robert Aiken,Rekha Chaudhary,Samuel Goldlust,Daniela A. Bota,Paul Duic,Jai Grewal,Heinrich Elinzano,Steven A. Toms,Kevin O. Lillehei,Tom Mikkelsen,Tobias Walbert,Steven R. Abram,Andrew Brenner,Steven Brem,Matthew G. Ewend,Simon Khagi,Jana Portnow,Lyndon Kim,William G. Loudon,Reid C. Thompson,David Avigan,Karen Fink,Francois J. Geoffroy,Scott Lindhorst,Jose Lutzky,Andrew E. Sloan,Gabriele Schackert,Dietmar Krex,Hans Jorg Meisel,Julian Wu,Raphael P. Davis,Christopher Duma,Arnold B. Etame,David Mathieu,Santosh Kesari,David Piccioni,Manfred Westphal,David S. Baskin,Pamela Z. New,Michel Lacroix,Sven Axel May,Timothy J. Pluard,Victor Tse,Richard M. Green,John L. Villano,Michael Pearlman,Kevin Petrecca,Michael Schulder,Lynne Taylor,Anthony E. Maida,Robert M. Prins,Timothy F. Cloughesy,Paul Mulholland,Marnix L. Bosch +68 more
TL;DR: This Correction corrects an error in the spelling of one of the author names and correct versions of the affected sentence are indicated.