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Paola A. Guerrero
Researcher at University of Texas MD Anderson Cancer Center
Publications - 35
Citations - 1022
Paola A. Guerrero is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 10, co-authored 25 publications receiving 480 citations. Previous affiliations of Paola A. Guerrero include University of Texas System.
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Journal ArticleDOI
Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer
Vincent Bernard,D. U. Kim,D. U. Kim,F. Anthony San Lucas,J. Castillo,Kelvin Allenson,Feven C Mulu,Bret M. Stephens,Jonathan Huang,Alexander Semaan,Paola A. Guerrero,Nabiollah Kamyabi,Jun Zhao,Mark W. Hurd,Eugene J. Koay,Cullen M. Taniguchi,Joseph M. Herman,Milind Javle,Robert A. Wolff,Matthew H.G. Katz,Gauri R. Varadhachary,Anirban Maitra,Hector A Alvarez +22 more
TL;DR: In a prospective cohort of pancreatic cancer patients, longitudinal monitoring using liquid biopsy samples through exoDNA and ctDNA provides both predictive and prognostic information relevant to therapeutic stratification.
Journal ArticleDOI
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.
Vincent Bernard,Alexander Semaan,Jonathan Huang,F. Anthony San Lucas,Feven C Mulu,Bret M. Stephens,Paola A. Guerrero,Yanqing Huang,Jun Zhao,Nabiollah Kamyabi,Subrata Sen,Paul Scheet,Cullen M. Taniguchi,Michael P. Kim,Ching Wei D. Tzeng,Matthew Harold Katz,Aatur D. Singhi,Anirban Maitra,Hector A Alvarez +18 more
TL;DR: The ability to perform high-resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer is demonstrated and might be a useful substrate to identify targets for cancer interception.
Posted ContentDOI
Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression
Vincent Bernard,Alexander Semaan,Jonathan Huang,F. Anthony San Lucas,Feven C Mulu,Bret M. Stephens,Paola A. Guerrero,Yanqing Huang,Jun Zhao,Nabiollah Kamyabi,Subrata Sen,Paul Scheet,Cullen M. Taniguchi,Michael P. Kim,Ching Wei D. Tzeng,Matthew Harold Katz,Aatur D. Singhi,Anirban Maitra,Hector A Alvarez +18 more
TL;DR: The ability to perform high resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer is demonstrated and might be a useful substrate to identify targets for cancer interception.
Journal ArticleDOI
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Tushar D. Bhagat,Dagny Von Ahrens,Meelad M. Dawlaty,Yiyu Zou,Joelle Baddour,Abhinav Achreja,Hongyun Zhao,Lifeng Yang,Brijesh Patel,Changsoo Kwak,Gaurav Choudhary,Shanisha Gordon-Mitchell,Srinivas Aluri,Sanchari Bhattacharyya,Srabani Sahu,Prafulla Bhagat,Yiting Yu,Matthias Bartenstein,Orsolya Giricz,Masako Suzuki,Davendra Sohal,Sonal Gupta,Paola A. Guerrero,Surinder K. Batra,Michael Goggins,Ulrich Steidl,John M. Greally,Beamon Agarwal,Kith Pradhan,Debabrata Banerjee,Deepak Nagrath,Anirban Maitra,Amit Verma +32 more
TL;DR: In PDAC, a tumor-mediated lactate flux is associated with widespread epigenomic reprogramming that is seen during CAF formation.
Posted ContentDOI
Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies
Jaewon J. Lee,Vincent Bernard,Alexander Semaan,Maria E. Monberg,Jonathan Huang,Bret M. Stephens,Daniel Lin,Brian Weston,Manoop S. Bhutani,Cara Haymaker,Chantale Bernatchez,Cullen M. Taniguchi,Anirban Maitra,Paola A. Guerrero +13 more
TL;DR: The application of single-cell RNA sequencing to diagnostic pancreatic cancer biopsies provides in-depth transcriptomic characterization of the tumor epithelium and microenvironment, while minimizing potential artifacts introduced by an intervening ex vivo passaging step.