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Paola Bet
Researcher at University of Genoa
Publications - 8
Citations - 542
Paola Bet is an academic researcher from University of Genoa. The author has contributed to research in topics: Secretion & Gene expression. The author has an hindex of 7, co-authored 7 publications receiving 537 citations.
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Journal ArticleDOI
Developmental regulation of IgM secretion: The role of the carboxy-terminal cysteine
Roberto Sitia,Roberto Sitia,Michael S. Neuberger,Cristina M. Alberini,Paola Bet,Anna M. Fra,Caterina Valetti,Gareth T. Williams,Cesar Milstein +8 more
TL;DR: In B and plasma cells, Cys-575 is involved both in the polymerization of IgM and in intracellular retention of unpolymerized intermediates.
Journal ArticleDOI
Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents
TL;DR: It is reported that the addition of reducing agents to the culture medium, at concentrations which do not affect cell viability, terminal glycosylation, or retention of proteins in the endoplasmic reticulum through the KDEL mechanism, induces secretion of IgM assembly intermediates by both B and plasma cells.
Journal ArticleDOI
Ovotransferrin and ovotransferrin receptor expression during chondrogenesis and endochondral bone formation in developing chick embryo
Chiara Gentili,Roberto Doliana,Paola Bet,Giuliano Campanile,Alfonso Colombatti,Fiorella Descalzi Cancedda,Ranieri Cancedda +6 more
TL;DR: The existence of autocrine and paracrine loops involving ovotransferrin and its receptor during chondrogenesis and endochondral bone formation is discussed.
Journal ArticleDOI
The efficiency of cysteine-mediated intracellular retention determines the differential fate of secretory IgA and IgM in B and plasma cells.
TL;DR: It is demonstrated that the differential retention of IgM and IgA subunits by myeloma transfectants is mainly due to the presence of an acidic residue upstream the α chain C‐terminal cysteine.
Journal ArticleDOI
The developmentally regulated avian Ch21 lipocalin is an extracellular fatty acid-binding protein.
Fiorella Descalzi Cancedda,Mara Malpeli,Chiara Gentili,Vincenzo Di Marzo,Paola Bet,Mariella F. Carlevaro,Silvia Cermelli,Ranieri Cancedda +7 more
TL;DR: Ch21, a developmentally regulated extracellular protein expressed in chick embryos and in cultured chondrocytes, was expressed in the baculovirus system, and the recombinant protein was purified to homogeneity by gel-filtration chromatography to rename the Ch21 protein as Extracellular fatty acid-binding rotein (Ex-FABP).