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Paolo Calligari
Researcher at University of Rome Tor Vergata
Publications - 32
Citations - 688
Paolo Calligari is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Allosteric regulation & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 12, co-authored 31 publications receiving 491 citations. Previous affiliations of Paolo Calligari include International School for Advanced Studies & École Normale Supérieure.
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Journal ArticleDOI
Molecular Investigation of SARS-CoV-2 Proteins and Their Interactions with Antiviral Drugs.
TL;DR: The molecular docking approach is exploited to analyze the affinity between different viral proteins and several inhibitors, originally developed for other viral infections, and shows that, in some cases, a relevant binding can be detected.
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Role of Proteolytic Enzymes In the Covid-19 Infection And Promising Therapeutic Approaches
Magda Gioia,Chiara Ciaccio,Paolo Calligari,Giovanna De Simone,Diego Sbardella,Grazia R. Tundo,Giovanni Francesco Fasciglione,Alessandra di Masi,Donato Di Pierro,Alessio Bocedi,Paolo Ascenzi,Massimo Coletta +11 more
TL;DR: What is known up to now on the role of specific proteolytic enzymes in these three steps of the viral replication and assembly and of most promising compounds designed to impair this vicious cycle is surveyed.
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Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors.
Sourav P. Mukherjee,Olesja Bondarenko,Olesja Bondarenko,Pekka Kohonen,Fernando Torres Andón,Táňa Brzicová,Isabel Gessner,Sanjay Mathur,Massimo Bottini,Paolo Calligari,Lorenzo Stella,Elena R. Kisin,Anna A. Shvedova,Anna A. Shvedova,Reija Autio,Heli Salminen-Mankonen,Riitta Lahesmaa,Bengt Fadeel +17 more
TL;DR: Compared the effects of two carbon-based nanomaterials, single-walled CNTs (SWCNTs) and graphene oxide (GO), on primary human monocyte-derived macrophages, results imply that CNT’s may be ‘sensed’ as pathogens by immune cells.
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Mutations in KCNK4 that Affect Gating Cause a Recognizable Neurodevelopmental Syndrome
Christiane K. Bauer,Paolo Calligari,Francesca Clementina Radio,Viviana Caputo,Maria Lisa Dentici,Nadia Falah,Frances A. High,Francesca Pantaleoni,Sabina Barresi,Andrea Ciolfi,Simone Pizzi,Alessandro Bruselles,Richard E. Person,Sarah Richards,Megan T. Cho,Daniela J. Claps Sepulveda,S. Pro,Roberta Battini,Giuseppe Zampino,Maria Cristina Digilio,Gianfranco Bocchinfuso,Bruno Dallapiccola,Lorenzo Stella,Marco Tartaglia +23 more
TL;DR: It is reported that de novo missense mutations in KCNK4 cause a recognizable syndrome with a distinctive facial gestalt, for which the acronym FHEIG is proposed (facial dysmorphism, hypertrichosis, epilepsy, intellectual disability/developmental delay, and gingival overgrowth).
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Nano-bio interactions: a neutrophil-centric view.
TL;DR: The impact of engineered nanomaterials on neutrophil and how neutrophils, in turn, may digest certain carbon-based materials such as carbon nanotubes and graphene oxide are discussed.