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Piotr Laidler
Researcher at Jagiellonian University Medical College
Publications - 96
Citations - 4300
Piotr Laidler is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: Cancer & Melanoma. The author has an hindex of 29, co-authored 96 publications receiving 3819 citations. Previous affiliations of Piotr Laidler include Jagiellonian University.
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Journal ArticleDOI
Elasticity of normal and cancerous human bladder cells studied by scanning force microscopy.
TL;DR: It is shown that normal cells have a Young's modulus of about one order of magnitude higher than cancerous ones, which might be attributed to a difference in the organisation of cell cytoskeletons and requires further studies.
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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Linda S. Steelman,William H. Chappell,Stephen L. Abrams,C. Ruth Kempf,Jacquelyn M. Long,Piotr Laidler,Sanja Mijatović,Danijela Maksimović-Ivanić,Franca Stivala,Maria Clorinda Mazzarino,Marco Donia,Paolo Fagone,Graziella Malaponte,Ferdinando Nicoletti,Massimo Libra,Michele Milella,Agostino Tafuri,Antonio Bonati,Jörg Bäsecke,Lucio Cocco,Camilla Evangelisti,Alberto M. Martelli,Giuseppe Montalto,Melchiorre Cervello,James A. McCubrey +24 more
TL;DR: The functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli are discussed and the recently described roles of these pathways in cancer stem cells, cellular senescence and aging are evaluated.
Journal ArticleDOI
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
William H. Chappell,Linda S. Steelman,Jacquelyn M. Long,Ruth C. Kempf,Stephen L. Abrams,Richard A. Franklin,Jörg Bäsecke,Franca Stivala,Marco Donia,Paolo Fagone,Graziella Malaponte,Maria Clorinda Mazzarino,Ferdinando Nicoletti,Massimo Libra,Danijela Maksimović-Ivanić,Sanja Mijatović,Giuseppe Montalto,Melchiorre Cervello,Piotr Laidler,Michele Milella,Agostino Tafuri,Antonio Bonati,Camilla Evangelisti,Lucio Cocco,Alberto M. Martelli,James A. McCubrey +25 more
TL;DR: This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging.
Journal ArticleDOI
Cancer cell detection in tissue sections using AFM
Małgorzata Lekka,Dorota Gil,Katarzyna Pogoda,Joanna Dulińska-Litewka,Robert Jach,Justyna Gostek,Olesya Klymenko,Szymon Prauzner-Bechcicki,Zbigniew Stachura,Joanna Wiltowska-Zuber,Krzysztof Okoń,Piotr Laidler +11 more
TL;DR: Despite of heterogeneity and complexity of cancer cell sections, the use of the Young's modulus as an indicator of cell elasticity allow for detection of cancer cells in tissue slices.
Journal ArticleDOI
Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
Nicole Marie Davis,Melissa L. Sokolosky,Kristin Stadelman,Stephen L. Abrams,Massimo Libra,Saverio Candido,Ferdinando Nicoletti,Jerry Polesel,Roberta Maestro,Antonino B. D'Assoro,Lyudmyla Drobot,Dariusz Rakus,Agnieszka Gizak,Piotr Laidler,Joanna Dulińska-Litewka,Jörg Bäsecke,Sanja Mijatović,Danijela Maksimović-Ivanić,Giuseppe Montalto,Melchiorre Cervello,Timothy L. Fitzgerald,Zoya N. Demidenko,Alberto M. Martelli,Lucio Cocco,Linda S. Steelman,James A. McCubrey +25 more
TL;DR: The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in association with suppression of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway.