P
Partha Sen
Researcher at Baylor College of Medicine
Publications - 21
Citations - 2899
Partha Sen is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Alveolar capillary dysplasia & Gene. The author has an hindex of 16, co-authored 21 publications receiving 2694 citations. Previous affiliations of Partha Sen include Northwestern University.
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Journal ArticleDOI
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
TL;DR: Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle.
Journal ArticleDOI
Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations.
Pawel Stankiewicz,Partha Sen,Samarth Bhatt,Mekayla Storer,Zhilian Xia,Bassem A. Bejjani,Zhishuo Ou,Joanna Wiszniewska,Daniel J. Driscoll,Juan Bolivar,Mislen Bauer,Elaine H. Zackai,Donna M. McDonald-McGinn,Malgorzata M.J. Nowaczyk,Mitzi L. Murray,Tamim H. Shaikh,Vicki Martin,Matthew Tyreman,Ingrid Simonic,Lionel Willatt,Joan Paterson,Sarju G. Mehta,Diana Rajan,Tomas W Fitzgerald,Susan M. Gribble,Elena Prigmore,Ankita Patel,Lisa G. Shaffer,Nigel P. Carter,Sau Wai Cheung,Claire Langston,Charles Shaw-Smith +31 more
TL;DR: Differences in microdeletions of FOXF1 were associated with hypoplastic left heart syndrome and gastrointestinal atresias, probably due to haploinsufficiency for the neighboring FOXC2 and FOXL1 genes, reveal the phenotypic consequences of gene alterations in cis.
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The maltase-glucoamylase gene: Common ancestry to sucrase-isomaltase with complementary starch digestion activities
Buford L. Nichols,Stephen E. Avery,Partha Sen,Dallas M. Swallow,Dagmar Hahn,Erwin E. Sterchi +5 more
TL;DR: The cloning and sequencing of human MGA gene is reported and its close evolutionary relationship to SI is demonstrated, suggesting that MGA and SI evolved by duplication of an ancestral gene, which itself had already undergone tandem gene duplication.
Journal ArticleDOI
Gene Expression in the Human Mammary Epithelium during Lactation: the Milk Fat Globule Transcriptome
Patricia Delfin Maningat,Partha Sen,Monique Rijnkels,Agneta L. Sunehag,Darryl L. Hadsell,Molly S. Bray,Morey W. Haymond +6 more
TL;DR: This paper is the first to describe the MFG transcriptome in sequential human samples over a 24 h period, providing valuable insights into gene expression in the human MEC.
Journal ArticleDOI
Expanding the phenotype of alveolar capillary dysplasia (ACD).
Partha Sen,Nivedita Thakur,David W. Stockton,Claire Langston,Bassem A. Bejjani,Bassem A. Bejjani +5 more
TL;DR: Understanding the clinical spectrum of ACD and the cloning of an "ACD gene" both have implications for counseling, for prenatal testing, and for understanding the molecular pathophysiology of ACd and other organ malformations that are associated with this condition.