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Claire Langston
Researcher at Baylor College of Medicine
Publications - 132
Citations - 8508
Claire Langston is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Lung & Interstitial lung disease. The author has an hindex of 47, co-authored 132 publications receiving 7954 citations. Previous affiliations of Claire Langston include McMaster University & Boston Children's Hospital.
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Journal ArticleDOI
Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
Gudrun Schiedner,Núria Morral,Núria Morral,Robin J. Parks,Ying Wu,Suzanne C. Koopmans,Claire Langston,Frank L. Graham,Arthur L. Beaudet,Arthur L. Beaudet,Stefan Kochanek,Stefan Kochanek +11 more
TL;DR: Using an adenoviral vector with all viral coding sequences deleted and containing the complete human α1-antitrypsin (PI) locus, intravenous injection in mice resulted in high levels of very stable expression for more than ten months and decreased acute and chronic toxicity.
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Diffuse lung disease in young children: application of a novel classification scheme.
Gail H. Deutsch,Lisa R. Young,Robin R. Deterding,Leland L. Fan,Sharon D. Dell,Judy A. Bean,Alan S. Brody,Lawrence M. Nogee,Bruce C. Trapnell,Claire Langston,Eric A. Albright,Frederic B. Askin,Peter B. Baker,Pauline M. Chou,Carlyne M. Cool,Susan Coventry,Ernest Cutz,Mary M. Davis,Megan K. Dishop,Csaba Galambos,Kathleen Patterson,William D. Travis,Susan E. Wert,Frances V. White +23 more
TL;DR: This retrospective cohort study identifies a diverse spectrum of lung disorders, largely unique to young children, that will enhance accurate description and diagnosis of these disorders.
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Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations.
Pawel Stankiewicz,Partha Sen,Samarth Bhatt,Mekayla Storer,Zhilian Xia,Bassem A. Bejjani,Zhishuo Ou,Joanna Wiszniewska,Daniel J. Driscoll,Juan Bolivar,Mislen Bauer,Elaine H. Zackai,Donna M. McDonald-McGinn,Malgorzata M.J. Nowaczyk,Mitzi L. Murray,Tamim H. Shaikh,Vicki Martin,Matthew Tyreman,Ingrid Simonic,Lionel Willatt,Joan Paterson,Sarju G. Mehta,Diana Rajan,Tomas W Fitzgerald,Susan M. Gribble,Elena Prigmore,Ankita Patel,Lisa G. Shaffer,Nigel P. Carter,Sau Wai Cheung,Claire Langston,Charles Shaw-Smith +31 more
TL;DR: Differences in microdeletions of FOXF1 were associated with hypoplastic left heart syndrome and gastrointestinal atresias, probably due to haploinsufficiency for the neighboring FOXC2 and FOXL1 genes, reveal the phenotypic consequences of gene alterations in cis.
Journal Article
Human lung growth in late gestation and in the neonate.
TL;DR: Surface area, lung volume, and total number of alveoli showed an exponential relationship to gestational age and crown-rump length, and air-space wall thickness showed a rapid decline starting at 28 wk gestation and is best related exponentially to age and Crown- rump length.
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New concepts in the pathology of congenital lung malformations
TL;DR: A malformation sequence based on airway obstruction during development is proposed as a unifying pathogenetic mechanism for some seemingly unrelated lesions.