P
Pascal De Tullio
Researcher at University of Liège
Publications - 128
Citations - 2442
Pascal De Tullio is an academic researcher from University of Liège. The author has contributed to research in topics: Benzothiadiazine & AMPA receptor. The author has an hindex of 26, co-authored 122 publications receiving 2106 citations. Previous affiliations of Pascal De Tullio include Université libre de Bruxelles.
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Journal ArticleDOI
Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties
Tahir Habila,Mebrouk Belghobsi,Mohamed-Zakaria Stiti,Eric Goffin,Pascal De Tullio,Gilles Faury,Bernard Pirotte,S. Khelili +7 more
TL;DR: A series of novel 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties were synthesized and pharmacologically evaluated as vasodilator agents as discussed by the authors.
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Independent Component Analysis and Statistical Modelling for theIdentification of Metabolomics Biomarkers in 1H-NMR Spectroscopy
TL;DR: A new methodology providing knowledge on specific 1H-NMR spectral areas via the identification of biomarkers and via the visualization of the effects caused by some external changes is presented, innovative because multi-factors studies and statistical confirmations of the factors effects are allowed together.
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4-Acylamino-4H-1,2,4-triazoles and related structures: new investigations of their chemical and physicochemical properties associated with their particular exocyclic amide function
Bernard Pirotte,Pascal De Tullio,Bernard Masereel,Marc Schynts,Jacques Delarge,Léon Dupont,Léopold Thunus +6 more
TL;DR: In this article, the acido-basic behavior of 4-acylamino-4H-1,2,4-triazoles and related structures, including 1-carboxymethyl-4-phenylacetylamino derivative has been selected as a particular triazolium salt bearing two acidic centres, a carboxylic acid group and an exocyclic amide group.
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Synthesis and biological effects of new 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides on insulin-secreting cells
Fabian Somers,Pascal De Tullio,Stéphane Boverie,Jean-Michel Dogné,Xavier de Leval,Marie-Hélène Antoine,Philippe Lebrun,Bernard Pirotte +7 more
TL;DR: 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides with nitro, amino or acetylamino groups in the 7-position have been synthesized in an attempt to discover new tissue-selective KATP-channel openers.
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3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as Potent KATP-Channel Activators: Structural Study and Influence of Stereochemistry
Pascal De Tullio,S. Khelili,Raogo Ouedraogo,Fabian Somers,Stéphane Boverie,Léon Dupont,Jeanine Fontaine,Marie-Hélène Antoine,Jacques Delarge,Philippe Lebrun,Bernard Pirotte +10 more
TL;DR: Pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides bearing a short and branched alkylamino side chain in the 3 position, appear to be powerful and tissue selective pancreatic KATP-channel activators.