P
Pascal De Tullio
Researcher at University of Liège
Publications - 128
Citations - 2442
Pascal De Tullio is an academic researcher from University of Liège. The author has contributed to research in topics: Benzothiadiazine & AMPA receptor. The author has an hindex of 26, co-authored 122 publications receiving 2106 citations. Previous affiliations of Pascal De Tullio include Université libre de Bruxelles.
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Journal Article
New trends in the design of drugs against Alzheimer's disease
TL;DR: This review presents an overview of the several strategies and new classes of compounds against AD and indicates some of these innovative approaches tend to delay onset of AD, while others are still symptomatic.
Journal ArticleDOI
3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Openers: Effect of 6,7-Disubstitution on Potency and Tissue Selectivity
Pascal De Tullio,Stéphane Boverie,B. Becker,Marie-Hélène Antoine,Q. A. Nguyen,Francotte Pierre,Stéphane Counerotte,S. Sebille,Bernard Pirotte,Philippe Lebrun +9 more
TL;DR: Radioisotopic and fluorimetric experiments performed with the most potent compound inhibiting insulin release (34, BPDZ 259, 6-chloro-7-fluoro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide) confirmed that the drug activated K(ATP) channels.
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Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
TL;DR: Radioisotopic and electrophysiological investigations performed with R/S-6-chloro-4-(3-chlorophenylaminocarbonylamino)-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran confirmed that the drug activated pancreatic KATP channels.
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Quality Assessment of Polygonum cuspidatum and Polygonum multiflorum by 1H NMR Metabolite Fingerprinting and Profiling Analysis.
Michel Frederich,Jean-Noël Wauters,Monique Tits,Charlotte Jason,Pascal De Tullio,Yvan Vander Heyden,Guorong Fan,Luc Angenot +7 more
TL;DR: An overview of the quality of P. cuspidatum and P. multiflorum samples available on the Chinese market is achieved and important metabolites for their discrimination are identified, using (1)H NMR-based metabolomics.
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Original 2-Alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP Channel Activity
Fabian Somers,Raogo Ouedraogo,Marie-Hélène Antoine,Pascal De Tullio,B. Becker,Jeanine Fontaine,Jacques Damas,L. Dupont,Benoît Rigo,Jacques Delarge,Philippe Lebrun,Bernard Pirotte +11 more
TL;DR: In conclusion, the newly synthesized quinazolinones interfere with insulin secretion and smooth muscle contractile activity and lack tissue selectivity.