P
Pascal De Tullio
Researcher at University of Liège
Publications - 128
Citations - 2442
Pascal De Tullio is an academic researcher from University of Liège. The author has contributed to research in topics: Benzothiadiazine & AMPA receptor. The author has an hindex of 26, co-authored 122 publications receiving 2106 citations. Previous affiliations of Pascal De Tullio include Université libre de Bruxelles.
Papers
More filters
Journal ArticleDOI
6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis
I. Kempen,Marc Hemmer,Stéphane Counerotte,Lionel Pochet,Pascal De Tullio,Jean-Michel Foidart,Silvia Blacher,Agnès Noël,Francis Frankenne,Bernard Pirotte +9 more
TL;DR: Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated.
Journal ArticleDOI
New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
Pierre Francotte,Eric Goffin,Pierre Fraikin,Pierre Lestage,Jean-Claude Van Heugen,Florian Gillotin,Laurence Danober,Jean-Yves Thomas,Patrice Chiap,Daniel-Henri Caignard,Bernard Pirotte,Pascal De Tullio +11 more
TL;DR: Results of this study clearly validated the positive impact of the fluorine atom on the alkyl chain at the 4-position of benzothiadiazine dioxides on activity and metabolic stability.
Journal ArticleDOI
Therapeutic and chemical developments of cholecystokinin receptor ligands.
TL;DR: The main biological role of CCK, the therapeutic potential ofCCK-A and CCK-B receptor agonists and antagonists and the common compounds from the different families of ligands are reviewed.
Journal ArticleDOI
AMPA receptor positive allosteric modulators: a patent review.
TL;DR: This article examines recent discoveries of new AMPA receptor modulators mainly described in the patent literature from 2008 to 2012 and indicates an important challenge is to discover an ideal drug candidate exhibiting appropriate in vivo activity after oral administration with an acceptable safety profile.
Journal ArticleDOI
3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.
Bernard Pirotte,Raogo Ouedraogo,Pascal De Tullio,S. Khelili,Fabian Somers,Stéphane Boverie,Léon Dupont,Jeanine Fontaine,Jacques Damas,Philippe Lebrun +9 more
TL;DR: It is suggested that 3-alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1, 1-dioxides may be considered as new examples of K(ATP) channel openers expressing a pharmacological profile similar to that of pinacidil and diazoxide.