P
Pascal De Tullio
Researcher at University of Liège
Publications - 128
Citations - 2442
Pascal De Tullio is an academic researcher from University of Liège. The author has contributed to research in topics: Benzothiadiazine & AMPA receptor. The author has an hindex of 26, co-authored 122 publications receiving 2106 citations. Previous affiliations of Pascal De Tullio include Université libre de Bruxelles.
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Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
Bernard Pirotte,Pascal De Tullio,Q. A. Nguyen,Fabian Somers,Pierre Fraikin,Xavier Florence,Philip Wahl,John Bondo Hansen,Philippe Lebrun +8 more
TL;DR: 6-chloro-3-alkylamino/cycloalkylaminos-4H-1,2,4-benzothiadiazine 1,1-dioxides appear to be more attractive than their previously described 7- chloro-substituted analogues as original drugs activating the SUR1/Kir6.2 K(ATP) channels.
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KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides.
Philippe Lebrun,B. Becker,Nicole Morel,Philippe Ghisdal,Marie-Hélène Antoine,Pascal De Tullio,Bernard Pirotte +6 more
TL;DR: Radioisotopic, electrophysiological and pharmacological investigations indicate that the marked vasorelaxant properties of the 3-alkylaminobenzothiadiazine 1,1-dioxides are related to the activation of smooth muscle K(ATP) channels.
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Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-Isopropylamino-4H-1,2,4- benzothiadiazine 1,1-dioxides: Toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability
Pascal De Tullio,Anne-Catherine Servais,Marianne Fillet,Florian Gillotin,Fabian Somers,Patrice Chiap,Philippe Lebrun,Bernard Pirotte +7 more
TL;DR: One of the most potent and SUR1-selective enantiomers, (R)-7-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide 13a, can be considered as a new lead candidate displaying improved physicochemical and pharmacological properties as well as improved metabolic stability compared to its nonhydroxylated counterpart, 1a.
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Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
S. Khelili,Xavier Florence,Mourad Bouhadja,Samia Abdelaziz,Nadia Mechouch,Yekhlef Mohamed,Pascal De Tullio,Philippe Lebrun,Bernard Pirotte +8 more
TL;DR: Ring-opened analogues of dihydrobenzopyran potassium channel openers were prepared and evaluated as putative PCOs on rat aorta rings (myorelaxant effect) and rat pancreatic beta-cells (inhibition of insulin secretion).
Journal ArticleDOI
Discovery and Characterization of R/S-N-3-Cyanophenyl-N′-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines
Michael Schnekenburger,Eric Goffin,Jin Young Lee,Jun Young Jang,Aloran Mazumder,Seungwon Ji,Bernard Rogister,Nafila Bouider,Florence Lefranc,Walter Miklos,Véronique Mathieu,Pascal De Tullio,Kyu-Won Kim,Mario Dicato,Walter Berger,Byung Woo Han,Robert Kiss,Bernard Pirotte,Marc Diederich +18 more
TL;DR: In this paper, a new series of N-aryl-N-3-cyanophenyl-N′-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea was synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells.