P
Patric J.D. Delhanty
Researcher at Erasmus University Rotterdam
Publications - 54
Citations - 2453
Patric J.D. Delhanty is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Ghrelin & Internal medicine. The author has an hindex of 24, co-authored 48 publications receiving 2120 citations. Previous affiliations of Patric J.D. Delhanty include Erasmus University Medical Center.
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Journal ArticleDOI
Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
C. Gauna,Patric J.D. Delhanty,Leo J. Hofland,Joop A. M. J. L. Janssen,Fabio Broglio,Fabio Broglio,Richard J. Ross,Ezio Ghigo,Aart Jan van der Lely +8 more
TL;DR: Gl glucose output by primary hepatocytes is time- and dose-dependently stimulated by AG and inhibited by UAG, and UAG counteracts the stimulatory effect of AG on glucose release.
Journal ArticleDOI
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
C. Gauna,F. M. Meyler,J A M J L Janssen,Patric J.D. Delhanty,Thierry Abribat,P. M. van Koetsveld,Leo J. Hofland,Fabio Broglio,Ezio Ghigo,A. J. van der Lely +9 more
TL;DR: This combined administration of acylated and unacylated ghrelin even significantly improved insulin sensitivity, compared with placebo, for at least 6 h, which warrants studies to investigate the long-term efficacy of this combination in the treatment of disorders with disturbed insulin sensitivity.
Journal ArticleDOI
Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
Patric J.D. Delhanty,B.C.J. van der Eerden,M. van der Velde,C. Gauna,H. A. P. Pols,Holger Jahr,Hideki Chiba,A. J. van der Lely,J.P.T.M. van Leeuwen +8 more
TL;DR: Overall,ghrelin gene expression was greater in differentiating than non-differentiating osteoblasts, but was not increased during culture in either group, suggesting new roles for ghrelin and UAG in modulating human osteoblast proliferation via a novel signal transduction pathway.
Journal ArticleDOI
The Use of Oxytocin to Improve Feeding and Social Skills in Infants With Prader-Willi Syndrome.
Maithé Tauber,Kader Boulanouar,Gwenaelle Diene,Sophie Çabal-Berthoumieu,Virginie Ehlinger,Pascale Fichaux-Bourin,Catherine Molinas,Sandy Faye,Marion Valette,Jeanne Pourrinet,Catie Cessans,Sylvie Viaux-Sauvelon,Céline Bascoul,Antoine Guedeney,Patric J.D. Delhanty,Vincent Geenen,Henri Martens,Françoise Muscatelli,David Cohen,Angèle Consoli,Pierre Payoux,Catherine Arnaud,Jean-Pierre Salles +22 more
TL;DR: OXT is well tolerated in infants with PWS and improves feeding and social skills and changes in circulating ghrelin and brain connectivity by functional MRI are documented.
Journal ArticleDOI
Unacylated Ghrelin Rapidly Modulates Lipogenic and Insulin Signaling Pathway Gene Expression in Metabolically Active Tissues of GHSR Deleted Mice
Patric J.D. Delhanty,Yuxiang Sun,Jenny A. Visser,Anke van Kerkwijk,Martin Huisman,Wilfred F. J. van IJcken,Sigrid M. A. Swagemakers,Roy G. Smith,Axel P. N. Themmen,Aart-Jan van der Lely +9 more
TL;DR: UAG rapidly modulates the expression of metabolically important genes in fat, muscle and liver of growth hormone secretagogue receptor-deleted mice indicating a direct, GHSR-independent, action of UAG to improve insulin sensitivity and metabolic profile.