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Patricia Amarante
Researcher at Amgen
Publications - 2
Citations - 3905
Patricia Amarante is an academic researcher from Amgen. The author has contributed to research in topics: Amyloid precursor protein & P3 peptide. The author has an hindex of 2, co-authored 2 publications receiving 3711 citations.
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Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.
Matthew R. Kaller,Scott Harried,Brian K. Albrecht,Patricia Amarante,Safura Babu-Khan,Michael D. Bartberger,James Brown,Ryan Brown,Kui Chen,Yuan Cheng,Martin Citron,Michael Croghan,Russell Graceffa,Dean Hickman,Ted Judd,Chuck Kriemen,Daniel La,Vivian S. W. Li,Patricia Lopez,Yi Luo,Craig E. Masse,Holger Monenschein,Thomas T. Nguyen,Lewis D. Pennington,Tisha San Miguel,E. Allen Sickmier,Robert C. Wahl,Matthew Weiss,Paul H. Wen,Toni Williamson,Stephen J. Wood,May Xue,Bryant Yang,Jianhua Zhang,Vinod F. Patel,Wenge Zhong,Stephen Hitchcock +36 more
TL;DR: Further optimizations that led to the discovery of inhibitor 16 as a novel, potent, and orally efficacious BACE inhibitor are reported.