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Patricia Ducy
Researcher at Baylor College of Medicine
Publications - 39
Citations - 18058
Patricia Ducy is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Osteoblast & Transcription factor. The author has an hindex of 27, co-authored 38 publications receiving 17348 citations. Previous affiliations of Patricia Ducy include University of Michigan & Baylor University.
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Journal ArticleDOI
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
TL;DR: Cloned cDNA encoding Osf2/Cbfa1 is identified as an osteoblast-specific transcription factor and as a regulator of osteoblasts differentiation.
Journal ArticleDOI
Leptin Inhibits Bone Formation through a Hypothalamic Relay: A Central Control of Bone Mass
Patricia Ducy,Michael Amling,Shu Takeda,Matthias Priemel,Arndt F. Schilling,Frank Timo Beil,Jianhe Shen,Charles Vinson,Johannes M. Rueger,Gerard Karsenty +9 more
TL;DR: This study identifies leptin as a potent inhibitor of bone formation acting through the central nervous system and therefore describes the central nature of bone mass control and its disorders.
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Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Guangbin Luo,Patricia Ducy,Marc D. McKee,Gerald J. Pinero,Evelyne M Loyer,Richard R. Behringer,Gerard Karsenty +6 more
TL;DR: Mgp, a mineral-binding ECM protein3 synthesized by vascular smooth-muscle cells and chondrocytes, is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo.
Journal ArticleDOI
Increased bone formation in osteocalcin-deficient mice
Patricia Ducy,Christelle Desbois,Brendan F. Boyce,Gerald J. Pinero,Beryl Story,Colin R. Dunstan,Erica Smith,Jeffrey Bonadio,Steven A. Goldstein,Caren M. Gundberg,Allan Bradley,Gerard Karsenty +11 more
TL;DR: This study provides the first evidence that osteocalcin is a determinant of bone formation, and generates osteocalin-deficient mice that develop a phenotype marked by higher bone mass and bones of improved functional quality.
Journal ArticleDOI
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Shu Takeda,Florent Elefteriou,Regis Levasseur,Xiuyun Liu,Liping Zhao,Keith L. Parker,Dawna L. Armstrong,Patricia Ducy,Patricia Ducy,Gerard Karsenty +9 more
TL;DR: A leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis is demonstrated, and the peripheral mediators of leptin antiosteogenic function appear to be neuronal.