C
Caren M. Gundberg
Researcher at Yale University
Publications - 98
Citations - 10032
Caren M. Gundberg is an academic researcher from Yale University. The author has contributed to research in topics: Osteocalcin & Bone remodeling. The author has an hindex of 52, co-authored 97 publications receiving 9419 citations. Previous affiliations of Caren M. Gundberg include McMaster University & University of Western Ontario.
Papers
More filters
Journal ArticleDOI
Increased bone formation in osteocalcin-deficient mice
Patricia Ducy,Christelle Desbois,Brendan F. Boyce,Gerald J. Pinero,Beryl Story,Colin R. Dunstan,Erica Smith,Jeffrey Bonadio,Steven A. Goldstein,Caren M. Gundberg,Allan Bradley,Gerard Karsenty +11 more
TL;DR: This study provides the first evidence that osteocalcin is a determinant of bone formation, and generates osteocalin-deficient mice that develop a phenotype marked by higher bone mass and bones of improved functional quality.
Journal ArticleDOI
Molecular Basis and Clinical Application of Biological Markers of Bone Turnover
TL;DR: Bone markers can be used for a variety of important purposes: as tools for basic bone biology research, for defining general physiological phenomenon in clinical studies or drug trials, and for following individual patients.
Journal ArticleDOI
Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin
Adele L. Boskey,Sergio J. Gadaleta,Caren M. Gundberg,S. B. Doty,Patricia Ducy,Gerard Karsenty +5 more
TL;DR: Test the hypothesis that, in addition to regulating osteoblastic activity, osteocalcin is involved in regulating mineral properties, a more sensitive assay of mineralization was used and spatially resolved data provide evidence that osteoccin is required to stimulate bone mineral maturation.
Journal ArticleDOI
Osteocalcin. Biochemical considerations and clinical applications.
Jane B. Lian,Caren M. Gundberg +1 more
TL;DR: The authors summarize the current understanding of the structure and function of osteocalcin in bone and evaluate the clinical studies done using serum osteoccin and urinary Gla to monitor bone turnover.
Journal ArticleDOI
Clinical use of biochemical markers of bone remodeling: current status and future directions.
Anne C. Looker,Douglas C. Bauer,Charles H. Chesnut,Caren M. Gundberg,Marc C. Hochberg,George G. Klee,Michael Kleerekoper,Nelson B. Watts,N. H. Bell +8 more
TL;DR: Biochemical markers of bone turnover provide a means of evaluating skeletal dynamics that complements static measurements of bone mineral density (BMD) and have potential in the clinical management of osteoporosis, but their use in this regard is not established.