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Patricia I. Dickson
Researcher at Washington University in St. Louis
Publications - 111
Citations - 3171
Patricia I. Dickson is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Enzyme replacement therapy & Mucopolysaccharidosis type I. The author has an hindex of 25, co-authored 94 publications receiving 2275 citations. Previous affiliations of Patricia I. Dickson include University of California, Los Angeles & Los Angeles Biomedical Research Institute.
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Journal ArticleDOI
Genetic/familial high-risk assessment: Breast, ovarian, and pancreatic, version 2.2021
Mary B. Daly,Tuya Pal,Michael Berry,Saundra S. Buys,Patricia I. Dickson,Susan M. Domchek,Ahmed Elkhanany,Susan Hatters Friedman,Michael Goggins,Mollie L. Hutton,Beth Y. Karlan,Seema A. Khan,Catherine Klein,Wendy Kohlmann,Allison W. Kurian,Christine Laronga,Jennifer K. Litton,Julie S. Mak,Carolyn S. Menendez,Sofia D. Merajver,Barbara S. Norquist,Kenneth Offit,Holly J. Pederson,Gwen Reiser,Leigha Senter-Jamieson,Kristen M. Shannon,Rebecca Shatsky,Kala Visvanathan,Jeffrey N. Weitzel,Myra J. Wick,Kari B. Wisinski,Matthew B. Yurgelun,Susan Darlow,Mary A. Dwyer +33 more
TL;DR: The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants associated with increased risk of breast, ovarian, and pancreatic cancer and recommended approaches to genetic testing/counseling and management strategies as mentioned in this paper.
Journal ArticleDOI
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020.
Mary B. Daly,Robert Pilarski,Matthew B. Yurgelun,Michael Berry,Saundra S. Buys,Patricia I. Dickson,Susan M. Domchek,Ahmed Elkhanany,Susan Hatters Friedman,Judy Garber,Michael Goggins,Mollie L. Hutton,Seema A. Khan,Catherine Klein,Wendy Kohlmann,Allison W. Kurian,Christine Laronga,Jennifer K. Litton,Julie S. Mak,Carolyn S. Menendez,Sofia D. Merajver,Barbara S. Norquist,Kenneth Offit,Tuya Pal,Holly J. Pederson,Gwen Reiser,Kristen M. Shannon,Kala Visvanathan,Jeffrey N. Weitzel,Myra J. Wick,Kari B. Wisinski,Mary A. Dwyer,Susan Darlow +32 more
TL;DR: These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding criteria for high-penetrance genes associated with breast and ovarian cancer beyond BRCA1/2, pancreas screening and genesassociated with pancreatic cancer, genetic testing for the purpose of systemic therapy decision-making, and testing for people with Ashkenazi Jewish ancestry.
Journal ArticleDOI
Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
Emil D. Kakkis,Emil D. Kakkis,Michael F. McEntee,Carole Vogler,Steven Q. Le,Beth Levy,Pavel V. Belichenko,William C. Mobley,Patricia I. Dickson,Stephen Hanson,Merry Passage +10 more
TL;DR: The IT route of ERT administration may be an effective way to treat the central nervous system disease in MPS I and could be applicable to other lysosomal storage disorders.
Journal ArticleDOI
Intrathecal enzyme replacement therapy: Successful treatment of brain disease via the cerebrospinal fluid
Patricia I. Dickson,Michael F. McEntee,Carole Vogler,Steven Q. Le,Beth Levy,Maryn Peinovich,Stephen Hanson,Merry Passage,Emil D. Kakkis +8 more
TL;DR: The successful use of enzyme therapy via the CSF represents a potentially useful approach for lysosomal storage disorders.
Journal ArticleDOI
Intrathecal delivery of protein therapeutics to the brain: a critical reassessment
TL;DR: Blood-brain barrier functions and cerebrospinal fluid dynamics and their relevance to drug delivery via the intrathecal route are reviewed, and several characteristics of protein therapeutics that can allow them to be successfully delivered intrathecally are outlined.