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Patricia Occhipinti
Researcher at Dartmouth College
Publications - 19
Citations - 1543
Patricia Occhipinti is an academic researcher from Dartmouth College. The author has contributed to research in topics: Septin & Cytoplasm. The author has an hindex of 14, co-authored 19 publications receiving 1249 citations. Previous affiliations of Patricia Occhipinti include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
RNA Controls PolyQ Protein Phase Transitions
Huaiying Zhang,Shana Elbaum-Garfinkle,Erin M Langdon,Nicole Taylor,Patricia Occhipinti,Andrew A. Bridges,Clifford P. Brangwynne,Amy S. Gladfelter +7 more
TL;DR: These findings suggest that mRNAs can encode not only genetic information but also the biophysical properties of phase-separated compartments, and indicate mRNA can bring individuality to assemblies.
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Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton
Andrew A. Bridges,Andrew A. Bridges,Maximilian S. Jentzsch,Patrick W. Oakes,Patricia Occhipinti,Amy S. Gladfelter,Amy S. Gladfelter +6 more
TL;DR: Fungal and human septins can distinguish between different degrees of micron-scale curvature in cells, suggesting that this property of the septin cytoskeleton provides a cell with a mechanism to sense its local shape.
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Septin assemblies form by diffusion-driven annealing on membranes
Andrew A. Bridges,Huaiying Zhang,Huaiying Zhang,Shalin B. Mehta,Patricia Occhipinti,Tomomi Tani,Amy S. Gladfelter,Amy S. Gladfelter +7 more
TL;DR: This work defines a key role of the membrane in directing septin filament formation in live cells and reconstituted dynamic septin polymerization, using purified components and finds that septins grow into filaments and form higher-order structures by diffusing, colliding, and annealing on the plasma membrane.
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Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals
Bradley S. DeMay,Xiaobo Bai,Louisa Howard,Patricia Occhipinti,Rebecca A. Meseroll,Elias T. Spiliotis,Rudolf Oldenbourg,Rudolf Oldenbourg,Amy S. Gladfelter +8 more
TL;DR: Polarized fluorescence microscopy reveals that septins across diverse species assemble into similar higher-order structures consisting of dynamic, paired filaments.
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Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control.
TL;DR: Nonrandom cyclin transcript localization is important for cell-cycle timing control and arises due to polyQ-dependent behavior of an RNA-binding protein, suggesting that this is a broadly exploited mechanism to produce spatially variable transcripts and heterogeneous cell behaviors.