P
Patricia W. Pan
Researcher at Structural Genomics Consortium
Publications - 8
Citations - 1081
Patricia W. Pan is an academic researcher from Structural Genomics Consortium. The author has contributed to research in topics: Binding site & Acetylation. The author has an hindex of 8, co-authored 8 publications receiving 970 citations. Previous affiliations of Patricia W. Pan include University of Toronto & University of Cambridge.
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Journal ArticleDOI
Structure and biochemical functions of SIRT6.
Patricia W. Pan,Jessica L. Feldman,Mark K. Devries,Aiping Dong,Aled M. Edwards,Aled M. Edwards,John M. Denu +6 more
TL;DR: Evidence is provided that SIRT6-dependent histone deacetylation produces O-acetyl-ADP-ribose but at a rate ∼1,000 times slower than other highly active sirtuins, which implies a unique activating mechanism and/or the possibility that Sirt6 could act as an NAD+ metabolite sensor.
Journal ArticleDOI
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
Chao Xu,Chuanbing Bian,Wei Yang,Marek Galka,Hui Ouyang,Chen Chen,Wei Qiu,Huadong Liu,Amanda Jones,Farrell MacKenzie,Patricia W. Pan,Shawn S.-C. Li,Hengbin Wang,Jinrong Min +13 more
TL;DR: It is shown that the WD40 domain of EED, a PRC2 component, is a methyllysine histone-binding domain, and it is found that binding of different histone marks by EED differentially regulates the activity and specificity ofPRC2.
Journal ArticleDOI
MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1
Xiangzhi Li,Callie A.S. Corsa,Patricia W. Pan,Lipeng Wu,David J. P. Ferguson,Xiaochun Yu,Jinrong Min,Yali Dou +7 more
TL;DR: This study revealed a novel chromatin-based mechanism that regulates the DNA damage repair process, and suggested that Mof-mediated H4 K16 acetylation and an intact acidic pocket on H2A.X were essential for the recruitment of Mdc1.
Journal ArticleDOI
Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases
Abdellah Allali-Hassani,Patricia W. Pan,Patricia W. Pan,Ludmila Dombrovski,Rafael Najmanovich,Rafael Najmanovich,Wolfram Tempel,Aiping Dong,Peter Loppnau,Fernando Martin,Janet M. Thornton,Janet M. Thornton,Janet Thonton,Janet Thonton,Aled M. Edwards,Aled M. Edwards,Alexey Bochkarev,Alexey Bochkarev,Alexander N. Plotnikov,Alexander N. Plotnikov,Masoud Vedadi,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith +22 more
TL;DR: The family-wide analysis of the screening and structural data provides a comprehensive, high-level view of the determinants of substrate binding, the mechanisms of inhibition by substrates and environmental toxins, and the functions of the orphan family members SULT1C3 and SULT4A1.
Journal ArticleDOI
Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.
Yahong Guo,Nataliya Nady,Chao Qi,Abdellah Allali-Hassani,Haizhong Zhu,Patricia W. Pan,Melanie A. Adams-Cioaba,Maria F. Amaya,Aiping Dong,Masoud Vedadi,Matthieu Schapira,Randy J. Read,Cheryl H. Arrowsmith,Jinrong Min +13 more
TL;DR: L3MBTL2, a human homolog of Drosophila Sfmbt critical for Hox gene silencing, is demonstrated to preferentially recognize lower methylation states of several histone-derived peptides through its fourth MBT repeat, revealing its unique asymmetric rhomboid architecture.