P
Patrick Mayeux
Researcher at University of Paris
Publications - 189
Citations - 11518
Patrick Mayeux is an academic researcher from University of Paris. The author has contributed to research in topics: Erythropoietin receptor & Phosphorylation. The author has an hindex of 59, co-authored 187 publications receiving 10582 citations. Previous affiliations of Patrick Mayeux include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
Murine erythroleukaemia cells (Friend cells) possess high-affinity binding sites for erythropoietin.
TL;DR: It is shown in this paper that both uncommitted and committed, benzidine‐positive, cells bind iodinated erythropoietin, and if these binding sites represent true hormone receptors, their presence on a permanent cell line should facilitate erythroid receptor purification.
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A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome
Sabrina Bondu,Anne-Sophie Alary,Carine Lefevre,Alexandre Houy,Grace Jung,Thibaud Lefebvre,David Rombaut,Ismael Boussaid,Abderrahmane Bousta,François Guillonneau,Prunelle Perrier,Samar Alsafadi,Michel Wassef,Raphaël Margueron,Alice Rousseau,Nathalie Droin,Nicolas Cagnard,Sophie Kaltenbach,Sophie Kaltenbach,Susann Winter,Anne Sophie Kubasch,Didier Bouscary,Valeria Santini,Andrea Toma,Mathilde Hunault,Aspasia Stamatoullas,Emmanuel Gyan,Thomas Cluzeau,Uwe Platzbecker,Lionel Ades,Hervé Puy,Marc-Henri Stern,Zoubida Karim,Patrick Mayeux,Elizabeta Nemeth,Sophie Park,Tomas Ganz,Léon Kautz,Olivier Kosmider,Michaela Fontenay +39 more
TL;DR: Hpcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.
Journal ArticleDOI
Targeting translation in acute myeloid leukemia: a new paradigm for therapy?
Jerome Tamburini,Alexa S. Green,Nicolas Chapuis,Valérie Bardet,Catherine Lacombe,Patrick Mayeux,Didier Bouscary +6 more
TL;DR: This work has shown that translation inhibition could be achieved by directly targeting the translation initiating complex using the 4EGI-1 compound, anti-eIF4E antisense oligonucleotides or the antiviral drug ribavirin or by second generation mTOR inhibitors (TORkinhibs).
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Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)
Didier Bouscary,Carinne Lecoq-Lafon,Stany Chrétien,Simona Zompi,Serge Fichelson,Odile Muller,Françoise Porteu,Isabelle Dusanter-Fourt,Sylvie Gisselbrecht,Patrick Mayeux,Catherine Lacombe +10 more
TL;DR: It is shown that upon thrombopoietin (Tpo) stimulation the two adapter proteins Gab1 and Gab2 are strongly tyrosine phosphorylated and associated with Shc, SHP2, PI 3-kinase and Grb2 in mpl-expressing UT7 cells, and Y112 located in the C-terminal cytoplasmic domain of mpl is required for Gab1/2 tyrosin phosphorylation.
Journal ArticleDOI
Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone
Bomee Chung,Frédérique Verdier,Pavle Matak,Jean-Christophe Deschemin,Patrick Mayeux,Sophie Vaulont +5 more
TL;DR: It is shown that on costatin M administration in vivo increases hepcidin expression and leads to significantly decreased serum iron levels, which supports a role for modulators of oncostatin M signaling pathway in treating iron disorders.