Simona Zompi

TL;DR: Dengue provides a striking example of a human viral infection where convergent immune signatures can be identified in multiple individuals, and could facilitate surveillance of immunological memory in communities.

TL;DR: Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines.

TL;DR: It is shown that cytotoxicity, but not cytokine production, is triggered by NKG2D in activated NK cells lacking either DAP12 or the Syk family members Syk and ZAP70, and that alternative associations between a receptor and its adaptors may provide a single receptor with a dual 'on-switch', giving mouse NK cells more choices through which to trigger cytot toxicity.

TL;DR: The results suggest that exocytosis of cytotoxic granules, but not cellular polarization toward targets, depends on intracellular calcium rise during NK cell cytotoxicity, and in vivo, PLC-gamma2 regulates selective facets of innate immunity.

TL;DR: The cross-reactive B cell immune response dominates during secondary DENV infections in humans, and this study enabled the development of increased technical and research capacity of Nicaraguan scientists and the implementation of several new immunological assays in the field.