Paul E. O'Maille

TL;DR: Recent developments in the field of triterpene biosynthesis are reviewed, an overview of the genes and enzymes that have been identified to date are given, and strategies for discovering new triterpenes pathways are discussed.

TL;DR: The reciprocal interconversion of catalytic specificities between two distinct yet evolutionarily related terpene synthases is reported, providing a simplified means for mapping structural features that are responsible for functional attributes and a strategy for identifying residues that differentiate divergent biosynthetic properties in phylogenetically related terPene synthase.

TL;DR: The first systematic quantitative characterization of a catalytic landscape underlying the evolution of sesquiterpene chemical diversity is reported, providing a measure of the mutational accessibility of phenotypic variability among a diverging lineage of terpene synthases.

TL;DR: The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16ink4A have been identified.

TL;DR: The phylogenetic analysis suggests that expansion of OSC members in higher plants has occurred mainly through tandem duplication followed by positive selection and diversifying evolution, and consolidated the previous suggestion that dicot triterpene synthases have been derived from an ancestral lanosterol synthase instead of directly from their cycloartenol synthases.