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Paul R. Jamieson
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 7
Citations - 702
Paul R. Jamieson is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Transcriptome & Population. The author has an hindex of 7, co-authored 7 publications receiving 455 citations. Previous affiliations of Paul R. Jamieson include University of Melbourne.
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Journal ArticleDOI
High-resolution 3D imaging of fixed and cleared organoids
Johanna F. Dekkers,Maria Alieva,Lianne M Wellens,Hendrikus C R Ariese,Paul R. Jamieson,Annelotte M. Vonk,Gimano D. Amatngalim,Huili Hu,Koen C. Oost,Hugo J. Snippert,Jeffrey M. Beekman,Ellen J. Wehrens,Jane E. Visvader,Jane E. Visvader,Hans Clevers,Anne C. Rios +15 more
TL;DR: A detailed protocol for performing high-resolution 3D imaging of entire organoids harboring fluorescence reporters and following immunolabeling is provided, applicable to a wide range of organoids of differing origins and of various sizes and shapes.
Journal ArticleDOI
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling.
Bhupinder Pal,Bhupinder Pal,Yunshun Chen,Yunshun Chen,François Vaillant,François Vaillant,Paul R. Jamieson,Lavinia Gordon,Anne C. Rios,Anne C. Rios,Stephen Wilcox,Nai Yang Fu,Nai Yang Fu,Kevin H. Liu,Felicity C. Jackling,Melissa J. Davis,Melissa J. Davis,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Gordon K. Smyth,Gordon K. Smyth,Jane E. Visvader,Jane E. Visvader +23 more
TL;DR: Findings point to a developmental hierarchy in which a basal-like gene expression program prevails in the early post-natal gland prior to the specification of distinct lineage signatures, and the presence of cellular intermediates that may serve as transit or lineage-primed cells.
Journal ArticleDOI
Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Nai Yang Fu,Anne C. Rios,Anne C. Rios,Bhupinder Pal,Bhupinder Pal,Charity W. Law,Charity W. Law,Paul R. Jamieson,Ruijie Liu,François Vaillant,François Vaillant,Felicity C. Jackling,Kevin H. Liu,Gordon K. Smyth,Gordon K. Smyth,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Matthew E. Ritchie,Matthew E. Ritchie,Jane E. Visvader,Jane E. Visvader +21 more
TL;DR: Interestingly, the deeply quiescent MaSC subset (Lgr5+Tspan8hi) resides within the proximal region throughout life, and has a transcriptome strikingly similar to that of claudin-low tumours.
Journal ArticleDOI
Derivation of a robust mouse mammary organoid system for studying tissue dynamics
Paul R. Jamieson,Paul R. Jamieson,Johanna F. Dekkers,Johanna F. Dekkers,Anne C. Rios,Anne C. Rios,Nai Yang Fu,Nai Yang Fu,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +12 more
TL;DR: Optimized in vitro conditions for the efficient generation of mouse mammary organoids that recapitulate features of mammary tissue architecture and function can be applied to understand tissue dynamics and cell-fate decisions are described.
Journal ArticleDOI
Essential role for a novel population of binucleated mammary epithelial cells in lactation.
Anne C. Rios,Nai Yang Fu,Nai Yang Fu,Paul R. Jamieson,Bhupinder Pal,Bhupinder Pal,Lachlan Whitehead,Kevin R. Nicholas,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +12 more
TL;DR: The findings demonstrate an important physiological role for polyploid mammary epithelial cells in lactation, and suggest that binucleated cells evolved to maximize milk production and promote the survival of offspring across all mammalian species.