F
Felicity C. Jackling
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 7
Citations - 417
Felicity C. Jackling is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Transcriptome & Morphogenesis. The author has an hindex of 6, co-authored 7 publications receiving 295 citations. Previous affiliations of Felicity C. Jackling include University of Melbourne.
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Journal ArticleDOI
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling.
Bhupinder Pal,Bhupinder Pal,Yunshun Chen,Yunshun Chen,François Vaillant,François Vaillant,Paul R. Jamieson,Lavinia Gordon,Anne C. Rios,Anne C. Rios,Stephen Wilcox,Nai Yang Fu,Nai Yang Fu,Kevin H. Liu,Felicity C. Jackling,Melissa J. Davis,Melissa J. Davis,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Gordon K. Smyth,Gordon K. Smyth,Jane E. Visvader,Jane E. Visvader +23 more
TL;DR: Findings point to a developmental hierarchy in which a basal-like gene expression program prevails in the early post-natal gland prior to the specification of distinct lineage signatures, and the presence of cellular intermediates that may serve as transit or lineage-primed cells.
Journal ArticleDOI
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.
Anne C. Rios,Anne C. Rios,Bianca D. Capaldo,François Vaillant,Bhupinder Pal,Ravian L. van Ineveld,Caleb A. Dawson,Yunshun Chen,Emma Nolan,Nai Yang Fu,Felicity C. Jackling,Sapna Devi,David Clouston,Lachlan Whitehead,Gordon K. Smyth,Scott N. Mueller,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +18 more
TL;DR: A rapid, large-scale single-cell resolution 3D imaging protocol based on a one-step clearing agent that allows visualization of normal tissue architecture and entire tumors at cellular resolution is reported.
Journal ArticleDOI
Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Nai Yang Fu,Anne C. Rios,Anne C. Rios,Bhupinder Pal,Bhupinder Pal,Charity W. Law,Charity W. Law,Paul R. Jamieson,Ruijie Liu,François Vaillant,François Vaillant,Felicity C. Jackling,Kevin H. Liu,Gordon K. Smyth,Gordon K. Smyth,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Matthew E. Ritchie,Matthew E. Ritchie,Jane E. Visvader,Jane E. Visvader +21 more
TL;DR: Interestingly, the deeply quiescent MaSC subset (Lgr5+Tspan8hi) resides within the proximal region throughout life, and has a transcriptome strikingly similar to that of claudin-low tumours.
Journal ArticleDOI
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence.
Nai Yang Fu,Nai Yang Fu,Nai Yang Fu,Bhupinder Pal,Yunshun Chen,Felicity C. Jackling,Felicity C. Jackling,Michael J. G. Milevskiy,Michael J. G. Milevskiy,François Vaillant,François Vaillant,Bianca D. Capaldo,Bianca D. Capaldo,Fusheng Guo,Kevin H. Liu,Kevin H. Liu,Anne C. Rios,Nicholas R. Lim,Andrew J. Kueh,David M. Virshup,Marco J Herold,Marco J Herold,Haley O. Tucker,Gordon K. Smyth,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +26 more
TL;DR: It is shown that ablation of the transcription factor Foxp1 in the mammary gland profoundly impairs ductal morphogenesis, resulting in a rudimentary tree throughout life.
Journal ArticleDOI
Chromosome-Level Alpaca Reference Genome VicPac3.1 Improves Genomic Insight Into the Biology of New World Camelids.
Mark F. Richardson,Kylie Munyard,Larry Croft,Theodore R. Allnutt,Felicity C. Jackling,Fahad Alshanbari,Matthew Jevit,Gus A. Wright,Rhys Cransberg,Ahmed Tibary,Polina L. Perelman,Belinda Appleton,Terje Raudsepp +12 more
TL;DR: A chromosome-level improved reference assembly for the alpaca genome VicPac3.1 presents a significant improvement in completeness, contiguity and accuracy over VicPac2 and is an important tool for the advancement of genomics research in all New World camelids.