Trust: The Social Virtues and the Creation of Prosperity

A decrease in the abundance and biodiversity of intestinal bacteria within the dominant phylum Firmicutes has been observed repeatedly in Crohn disease (CD) patients. In this study, we determined the composition of the mucosa-associated microbiota of CD patients at the time of surgical resection and 6 months later using FISH analysis. We found that a reduction of a major member of Firmicutes, Faecalibacterium prausnitzii, is associated with a higher risk of postoperative recurrence of ileal CD. A lower proportion of F. prausnitzii on resected ileal Crohn mucosa also was associated with endoscopic recurrence at 6 months. To evaluate the immunomodulatory properties of F. prausnitzii we analyzed the anti-inflammatory effects of F. prausnitzii in both in vitro (cellular models) and in vivo [2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced] colitis in mice. In Caco-2 cells transfected with a reporter gene for NF-kappaB activity, F. prausnitzii had no effect on IL-1beta-induced NF-kappaB activity, whereas the supernatant abolished it. In vitro peripheral blood mononuclear cell stimulation by F. prausnitzii led to significantly lower IL-12 and IFN-gamma production levels and higher secretion of IL-10. Oral administration of either live F. prausnitzii or its supernatant markedly reduced the severity of TNBS colitis and tended to correct the dysbiosis associated with TNBS colitis, as demonstrated by real-time quantitative PCR (qPCR) analysis. F. prausnitzii exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-kappaB activation and IL-8 production. These results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment.

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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences

Earnings Management and Investor Protection: An International Comparison

The received wisdom tells us that the rigidity and inflexibility of European job markets relative to that in the United States is the reason why Europe has high unemployment. This paper argues that this broad brush analysis is simply too vague to be useful. Indeed it is probably positively misleading. Many labor market institutions that conventionally come under the heading of rigidities have no observable impact on unemployment and may otherwise serve a useful purpose.

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Unemployment and Labor Market Rigidities: Europe versus North America

A salient feature of the ’training market’ through which public training programmes are often organised is the external inspection of training providers The inspection of providers of Apprenticeship training in England has been shown to focus more on procedural than on substantive attributes From a statistical and qualitative analysis of the content of inspection reports on training providers, we infer that this proceduralist bias distorts information on training quality by type of provider Training sponsored by employers is made to appear less effective relative to that offered by specialist training organisations The informational distortion is largely limited to private sector employers: other employer categories perform similarly to specialist training providers

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Does inspection under-rate Apprenticeship training by employers? Evidence from England

The MarineGrid project in Ireland with Webcom

Abstract The creation and maintenance of Registers of Processing Activities (ROPA) are essential to meeting the General Data Protection Regulation (GDPR) and thus to demonstrate compliance based on the GDPR concept of accountability. To establish its effectiveness in meeting this obligation, we evaluate an ROPA semantic model, the Common Semantic Model–ROPA (CSM–ROPA). Semantic models and tools represent one solution to the compliance challenges faced by organisations: the heterogeneity of relevant data sources, and the lack of tool interoperability and agreed common standards. By surveying current practice and the literature we identify the requirements for GDPR accountability tools: digital exchange of data, automated accountability verification and privacy-aware data governance. A case study was conducted to analyse the expressivity and effectiveness of CSM–ROPA when used as an interoperable, machine-readable mediation layer to express the concepts in a comprehensive regulator-provided accountability framework used for GDPR compliance. We demonstrate that CSM–ROPA can express 98% of ROPA accountability terms and fully express nine of the ten European regulators' ROPA templates. We identify three terms for addition to CSM–ROPA, and we identify areas where CSM–ROPA relies on partial matches that indicate model limitations. These improvements to CSM–ROPA will provide comprehensive coverage of the regulator-supplied model. We show that tools based on CSM–ROPA can fully meet the requirements of compliance best practice when compared with either manual accountability approaches or a leading privacy software solution. 

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Support for Enhanced GDPR Accountability with the Common Semantic Model for ROPA (CSM-ROPA)

Im Rahmen des Artikels wird argumentiert, dass die institutionellen Rahmenbedingungen dazu fuhren, dass Schweizer Unternehmen - im Vergleich zu deutschen - in geringerem Ausmas auf ihre eigenen Lehrlinge zuruckgreifen, wenn es darum geht, freie Facharbeiterstellen in der Produktion zu decken

Paul Ryan

Papers

Does inspection under-rate Apprenticeship training by employers? Evidence from England

The MarineGrid project in Ireland with Webcom

Support for Enhanced GDPR Accountability with the Common Semantic Model for ROPA (CSM-ROPA)

Duale Ausbildung und Personalpolitik: So gleich und doch so fremd?

Bacterial DNA within granulomas of patients with Crohn's disease-detection by laser capture microdissection and PCR