P
Pauline Schaap
Researcher at University of Dundee
Publications - 148
Citations - 5266
Pauline Schaap is an academic researcher from University of Dundee. The author has contributed to research in topics: Dictyostelium discoideum & Dictyostelium. The author has an hindex of 41, co-authored 141 publications receiving 4851 citations. Previous affiliations of Pauline Schaap include University of Groningen & Leiden University.
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Journal ArticleDOI
Correlations between tip dominance, prestalk/prespore pattern, and CAMP-relay efficiency in slugs of Dictyostelium discoideum
Mei Wang,Pauline Schaap +1 more
TL;DR: Evidence is presented indicating that cAMP signaling may also be involved in the formation of the prestalk/prespore pattern in slugs of Dictyostelium discoideum.
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A Conserved Signalling Pathway for Amoebozoan Encystation that was Co-Opted for Multicellular Development
TL;DR: It is concluded that multicellular cAMP signalling was co-opted from PKA regulation of protist encystation with progressive refunctionalization of pathway components.
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Evolution of developmental signalling in Dictyostelid social amoebas.
TL;DR: This review summarizes the current understanding of developmental signalling in D. discoideum and its evolution and finds that for the most dominant pathways, evolutionary origins were retraced to a stress response in the unicellular ancestor, while modifications in the ancestral pathway were associated with acquisition of multicellular complexity.
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Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes.
Samar Kabbara,Anaïs Hérivaux,Thomas Dugé de Bernonville,Vincent Courdavault,Marc Clastre,Amandine Gastebois,Marwan Osman,Monzer Hamze,J. Mark Cock,Pauline Schaap,Nicolas Papon +10 more
TL;DR: This study provides an unprecedented overview of the structure and distribution of HKs in the Eukaryota and represents a first step toward deciphering the evolution of TCS signaling in living organisms.
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Characterization of a cAMP-stimulated cAMP Phosphodiesterase inDictyostelium discoideum
TL;DR: A cyclic nucleotide phosphodiesterase, PdeE, that harbors two cyclicucleotide binding motifs and a binuclear Zn2+-binding domain was characterized in Dictyostelium and is an allosteric enzyme, which is ∼4-fold activated by cAMP.