P
Pauline Schaap
Researcher at University of Dundee
Publications - 148
Citations - 5266
Pauline Schaap is an academic researcher from University of Dundee. The author has contributed to research in topics: Dictyostelium discoideum & Dictyostelium. The author has an hindex of 41, co-authored 141 publications receiving 4851 citations. Previous affiliations of Pauline Schaap include University of Groningen & Leiden University.
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Journal ArticleDOI
Regulation of size and pattern in the cellular slime molds
TL;DR: The available data indicate that oscillatory cAMP signaling is the main regulatory mechanism of cellular slime mold development, and induce stage- and cell-type-specific gene expression and control the generation of shape by coordinating the movement of individual cells.
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The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.
TL;DR: The cell–cell communication systems that control the developmental programme of D. discoideum are described, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation.
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Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).
TL;DR: It is shown that overexpression of ACG, a constitutively active adenylyl cyclase, which in wild-type cells is only expressed during spore germination, partially restores the coordination of cell movement and completely restores developmental gene expression in aca- cells.
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Postaggregative differentiation induction by cyclic AMP in Dictyostelium: Intracellular transduction pathway and requirement for additional stimuli
Pauline Schaap,Michiel M. van Lookeren Campagne,Roel van Driel,Wouter Spek,Peter J.M. van Haastert,Johan E. Pinas +5 more
TL;DR: The transduction pathway from the cell surface cAMP receptor to postaggregative gene expression may involve Ca2+ ions as intracellular messengers and a cAMP-induced increase in intrACEllular cAMP or cGMP levels is not involved in theTransduction pathway.
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Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium.
Pauline Schaap,M. Van Ments-Cohen,Ron D.M. Soede,Raymond Brandt,Richard A. Firtel,Wolfgang R. Dostmann,H.-G. Genieser,B. Jastorff,P. J. M. Van Haastert +8 more
TL;DR: Data indicate that surface cAMP receptors are the first targets for cAMP-induced gene expression, and argue against direct induction of expression of these genes by camp-induced PKA activation.